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5453-02-1

(2E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, commonly known as curcumin, is a natural phenolic compound derived from the rhizome of the turmeric plant. It is characterized by its vibrant yellow color and is widely recognized as a spice and food coloring agent. Curcumin has garnered significant attention for its potential health benefits, which include anti-inflammatory and antioxidant properties. (2E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one has been a staple in traditional medicine for centuries and continues to be the focus of research for its therapeutic potential in various medical conditions, such as cancer, diabetes, and neurodegenerative diseases. Furthermore, curcumin is being investigated for its possible neuroprotective and cognitive-enhancing effects.

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  • 5453-02-1 Structure

  • Basic information

    1. Product Name: (2E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one
    2. Synonyms: 1-(2-Hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one; Chalcone, 2'-hydroxy-3',4,4',6'-tetramethoxy-
    3. CAS NO:5453-02-1
    4. Molecular Formula: C19H20O6
    5. Molecular Weight: 344.3585
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 5453-02-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 558.5°C at 760 mmHg
    3. Flash Point: 200.2°C
    4. Appearance: N/A
    5. Density: 1.211g/cm3
    6. Vapor Pressure: 4.43E-13mmHg at 25°C
    7. Refractive Index: 1.588
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. CAS DataBase Reference: (2E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
    11. NIST Chemistry Reference: (2E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(5453-02-1)
    12. EPA Substance Registry System: (2E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one(5453-02-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 5453-02-1(Hazardous Substances Data)

5453-02-1 Usage

Uses

Used in Food Industry:
Curcumin is used as a spice and food coloring agent for its vibrant yellow color, adding visual appeal and flavor to various dishes.
Used in Traditional Medicine:
Curcumin has been employed in traditional medicine for centuries due to its anti-inflammatory and antioxidant properties, which contribute to its therapeutic potential in treating various medical conditions.
Used in Pharmaceutical Industry:
Curcumin is used as a potential therapeutic agent for various medical conditions, including cancer, diabetes, and neurodegenerative diseases, owing to its health benefits and ongoing research into its efficacy.
Used in Neuroprotection and Cognitive Enhancement:
Curcumin is being investigated for its potential neuroprotective and cognitive-enhancing effects, which could lead to its use in applications related to brain health and cognitive function.

Check Digit Verification of cas no

The CAS Registry Mumber 5453-02-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,5 and 3 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5453-02:
(6*5)+(5*4)+(4*5)+(3*3)+(2*0)+(1*2)=81
81 % 10 = 1
So 5453-02-1 is a valid CAS Registry Number.

5453-02-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

1.2 Other means of identification

Product number -
Other names 1-(2-Hydroxy-3,4,6-trimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5453-02-1 SDS

5453-02-1Relevant articles and documents

Synthesis and antimalarial evaluation of novel benzopyrano[4,3-b]benzopyran derivatives

Devakaram, Ruth,Black, David Stc.,Andrews, Katherine T.,Fisher, Gillian M.,Davis, Rohan A.,Kumar, Naresh

body text, p. 5199 - 5206 (2011/10/09)

7-Methoxyflavenes and 5,7,8-trimethoxyflavenes were found to undergo stereoselective acid-catalyzed rearrangement to generate the benzopyrano[4,3-b]benzopyran ring system present in the natural product, dependensin. Dependensin and its analogs were subjected to antimalarial growth inhibition assays against Plasmodium falciparum and found to have IC 50 values ranging between 1.9 and 3.9 μM.

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