54533-84-5

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 628-89-7 2-(2-Chloroethoxy)ethanol 

Downstream Products

• 41024-87-7 1,2-bis(5-hydroxy-3-oxa-1-pentyloxy)benzene ditosylate 
• 80639-60-7 4-Methyl-N,N-bis-{2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethyl}-benzenesulfonamide 
• 134252-89-4 3,5-Bis(5-tetrahydropyranyloxy-3-oxa-1-pentyloxy)toluene 
• 42607-87-4 17-(2H-tetrahydropyran-2'-yloxy)-3,6,9,12,15-pentaoxaheptadecan-1-ol 
• 1061303-11-4 2-[9-(4-allyloxyphenyl)-1,4,7-trioxanonan-1-yl]-tetrahydro-2H-pyran 
• 119319-04-9 5-(3,3-dimethylbutanoyl)-3-methyl-1,2-di(2-[2-(2-tetrahydropyranoyloxy)ethoxy]ethoxy)benzene 
• 672949-78-9 N-(4-chlorobenzyl)-2-(hydroxymethyl)-4-oxo-7-(2-(2-(tetrahydro-2H-pyran-2-yloxy)ethoxy)ethyl)-4,7-dihydrothieno[2,3-b]-pyridine-5-carboxamide 
• 88454-94-8 1,4-Di-O-benzyl-2,3-bis-O-<2-<2-(2-tetrahydropyranyloxy)ethoxy>ethyl>-L-threitol 
• 852866-26-3 1,3,5-tris(7'-hydroxy-2',5'-dioxa-1'-heptyl)benzene tri(2'-tetrahydropyranyl) ether 
• 114951-76-7 1-(benzyloxymethyl) triethylene glycol 
• 230620-73-2 2-{2-[2-(2-{2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-tetrahydro-pyran 
• 230620-74-3 2-[2-(2-{2-[2-(2-benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-tetrahydro-pyran 
• 161807-05-2 1,2-bis<2'-(2''-hydroxyethoxy)ethoxy>-4,5-dibromobenzene 

Relevant academic research and scientific papers

ANTI-CANCER NUCLEAR HORMONE RECEPTOR-TARGETING COMPOUNDS

The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.

NOVEL AROMATIC COMPOUND AND USE THEREOF

Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a pharmacologically acceptable salt: [wherein each substituent is as defined in the DESCRIPTION], has low toxicity, shows good pharmacokinetics, has an action to promote bone formation, and is useful for the prophylaxis or To treatment of metabolic bone diseases (osteoporosis, fibrous osteitis (hyperparathyroidism), osteomalacia, Paget's disease that influences the systemic bone metabolism parameter etc.) associated with a decrease in the bone formation ability as compared to the bone resorption capacity.

GOLD NANOPARTICLES AND METHODS OF MAKING AND USING GOLD NANOPARTICLES

Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

Doubly activated supramolecular reaction: Transesterification of acyclic oligoether esters with metal alkoxides

Transesterification reactions of acyclic oligoether esters E3-E10 with metal alkoxides were accelerated upon noncovalent complexation of the esters with metal ions. In the reaction of monovalent alkaline metal alkoxides, CH3ONa and CH3OK, plots of the observed rate constants kobs with respect to the chain length of E3-E10 showed selective acceleration of the transesterification. Compared with the shortest E3, which can hardly bind metal ion, 4.3- and 6.6-fold accelerations in the maxima were achieved in the combinations of E5/CH3ONa and E6/CH3OK, respectively. Supramolecular intermediate complex could be spectrometrically visualized by ESI-FT-ICR-MS in the course of reaction. Kinetic experiments, together with structural analyses by means of NMR, mass spectrometry, and DFT calculations of the intermediate complexes, indicate that a size-fit complex of host substitute with alkali metal ion allows strong electron withdrawing due to the close contact of the carbonyl oxygen to the metal ion, resulting in the selective rate enhancement of the reaction, while in the reaction of E3-E10 with a divalent alkaline earth metal alkoxide, (CH3- CH2O)2Ba, the kobs values increased stepwise with elongation of the side arm to attain an dramatic large acceleration. In comparison with the kobs of E3, 4610-fold acceleration was achieved in the reaction of E10. The double activation of the host substrate and guest counter nucleophile at once brings about this extraordinary rate acceleration. The strong wrapping complexation of long oligoether ester with barium ethoxide allows for the effective electron withdrawal from the ester carbonyl group (host activation) as well as separation of the accompanying guest alkoxide anions (guest activation).

A single-layer approach to electrochromic materials

This study is focused on the development of electrochromic (EC) materials that could be incorporated into electrically-driven switchable devices such as electrochromogenic glasses. The ultimate goal of this research is to depart from the complexity of the EC device construction which is in use today. Such construction consists of three layers each of them incorporating a specific functionality: the electrochromophore, the electrolyte and the ion storage, assembled between two transparent or reflective electrodes. In most of these conventional devices the electrolyte layer is a liquid or a gel. Since solid-state EC devices are of high commercial interest, we are exploring various avenues to reduce the number of layers to one layer that is all-solid and electrochromically/electrolytically and ionically functional. The design strategy is based on the use of polymers such as poly(epichlorohydrin-co- ethylene oxide), poly(vinyl butyral) and poly(ethylene-co-methacrylic acid) ionomer, to which EC properties were introduced by grafting reactions with specifically synthesized carbazole derivatives. A combination of analytical techniques was used to characterize the monomers and the carbazole-grafted polymers. A proof of concept was demonstrated for a single-layer, all-solid-state EC device consisting of a film of poly(ECH-co-EO) containing pendent carbazole groups, assembled between two transparent electrodes, Sn-doped In2O3 oxide-coated glasses.

Multivalent glycomimetics: synthesis of nonavalent mannoside clusters with variation of spacer properties

Oligosaccharide mimetics are important tools in the glycosciences. In this work, we have employed spaced glycodendrons for the synthesis of oligomannoside mimetics. Starting from a number of trivalent, branched molecular wedges, the preparation of nonavalent cluster mannosides was accomplished, which were varied with regard to the chemical characteristics of their spacer moieties and spacer lengths. For ligation of the various trivalent dendrons to the nonavalent target molecules peptide coupling was employed.

PREPARATION OF QUETIAPINE

The present invention discloses a process for the preparation of quetiapine, which comprises the reaction of dibenzo[b,f][1,4]thiazepin-11-ylamine with a compound of the general formula (II) as well as novel intermediates in the process.

Synthesis and characterization of network type single ion conductors

New single ion conductors were synthesized by grafting the allyl group-containing lithium salt, lithium bis(allylmalonato)borate (LiBAMB), onto allyl group-containing comb-branch polyacrylate or polymethacrylate ethers by means of hydrosilylation. The highest ambient temperature conductivity of 3.5 × 10-7 S cm-1 was obtained for a polyacrylate ether-based single ion conductor containing eight EO units in the side chain and five EO units in the cross-linking side chain, to which the anion was fixed with a salt concentration of EO/Li = 20. For polyacrylate ether-based single ion conductors, an increase of chain length in both side chains and cross-linking anion chains favors an increase of ionic conductivity. The addition of 50 wt % EC/DMC (1/1, wt/wt) increased the ionic conductivity by more than 2 orders of magnitude due to both the increase in ionic mobility from the liquid phase and the increase in the concentration of free ions from the high dielectric constant of the solvent. The preliminary Li/Li cycling profiles of dry polyacrylate- and polymethacrylate ether-based single ion conductors are encouraging as almost no concentration polarization or relaxation was observed. The observed increase in cell potential with cycling is apparently due to an increase in the interfacial impedance associated with the SEI layer, and the cell failure is accompanied by the decomposition of the ester bond of the polyacrylate backbone.

Synthesis of azacrown ethers modified with side-chains containing germanium

The reaction between ethanolamine (4) and tri- or tetraethylene tosylate (5) and (13) gave 9- and 12-membered monoazacrowns with a -CH2CH2OH residue on nitrogen, A-OH and B-OH, together with 18- and 24-membered diazacrown ethers with the same substituent on nitrogen, E-OH and F-OH. If 2-(2-aminoethoxy)ethanol (12) was used in the reaction described above, instead of 4, the final products, G-OH and H-OH, and K-OH and L-OH, have a longer side chain, -CH2CH2OCH2CH2OH, on nitrogen (Route 1). A series of reactions involving bromoethanol (6) and diethanolamine (9) formed, with 5 or 13, 18- and 24-membered monoazacrowns with the shorter substituent as described above, a 15-membered monoazacrown ether C-OH and an 18-membered D-OH. If 2-(2-chloroethoxy)ethanol (14) is used instead of 6, I-OH and J-OH are obtained (Route 2′). All these hydroxy azacrown ethers were made to react with 3-trimethylgermylpropionic acid (18) to give the corresponding germanium-containing A-L. A preliminary investigation was carried out on the cation transport capability of these germanium-containing azacrown ethers to observe whether germanium might enhance their cation transporting capability.