628-89-7Relevant articles and documents
A dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol synthesis method
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Paragraph 0061-0064; 0068; 0069; 0073; 0074; 0079; 0080, (2019/05/16)
The invention discloses a dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol synthesis method, which belongs to the field of organic synthesis. The method comprises: the molar ratio of 0.8 - 1.5: 0.3 diethylene glycol and catalyst in a double-mouth flask, and the double-mouth flask are respectively connected with two of the mouth of the funnel and a condenser; the use of a separatory funnel to drip the mixed acid in double-mouth flask, in 130 °C - 170 °C under reaction, during the reaction, the use of condenser to collect condensate; the condensate to the distillation is carried out, to obtain dichloro diethyl ether; double-mouth flask in the remaining liquid to filter, to obtain the 2 - chloroethyl phenoxy ethanol, wherein mixed acid include: mass ratio is 25 - 35:1 of concentrated hydrochloric acid is concentrated sulfuric acid. The embodiment of the invention the synthesis method provided not only can at the same time obtained by synthesizing dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol, but also, the method reaction is simple and controllable, mild reaction conditions, raw materials are safe and easily-obtained, so that the synthesis of the two more safe and controllable, the cost is cheaper.
Hydrolysis of Nitrite Esters: Putative Intermediates in the Biotransformation of Organic Nitrates
Buckell, Felicity,Hartry, Jeffrey D.,Rajalingam, Umarani,Bennett, Brian M.,Whitney, Ralph A.,Thatcher, Gregory R. J.
, p. 401 - 404 (2007/10/02)
Study and comparison of the pH-independent hydrolysis of eight alkyl nitrites shows 3-nitroso-1,2-glyceryl dinitrate, a putative intermediate in the biotransformation of glyceryl trinitrate, to be unexpectedly reactive and too labile to be detected as a biotransformation intermediate in aqueous solution, suggesting a role for neighbouring group participation by the β-nitrate group.
STUDY OF THERMAL CONVERSIONS OF ETHYLENE CHLOROHYDRIN (2-CHLOROETHANOL).
Zil'berman,Kolesnikov,Danov,Efremov,Pantina
, p. 2344 - 2347 (2007/10/02)
Ethylene chlorohydrin (ECH) is a widely used industrial solvent and reagent. When used at temperatures above 100-110 degree , ECH undergoes considerable decomposition. The authors of most publications, concerned with thermal stability of ECH, studied its hydrolysis in alkaline, acidic, and neutral solutions at temperatures up to 100 degree , and also free-radical decomposition of ECH at 430-496 degree in the gase phase. There is no information in the literature on the thermal stability of ECH in the liquid phase in the temperature range 110-150 degree . The purpose of the present work was to determine the principal relationships of thermal decomposition in anhydrous ECH in the liquid phase in the temperature range indicated above.