545396-65-4

Basic information

• Product Name: 8-[4-(4-trifluoromethyl-phenyl)-pyridin-2-yloxy]-quinoline
• CAS NO: 545396-65-4
• Molecular Weight: 366.342
• Mol File: 545396-65-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-[4-(4-trifluoromethyl-phenyl)-pyridin-2-yloxy]-quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 8-[4-(4-trifluoromethyl-phenyl)-pyridin-2-yloxy]-quinoline(545396-65-4)
• EPA Substance Registry System: 8-[4-(4-trifluoromethyl-phenyl)-pyridin-2-yloxy]-quinoline(545396-65-4)

Safety Data

• Hazardous Substances Data: 545396-65-4(Hazardous Substances Data)

Upstream product

• 1415666-44-2 C₁₄H₉BrN₂O 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 148-24-3 8-quinolinol 
• 545396-54-1 2-chloro-4-[4-(trifluoromethyl)phenyl]pyridine 
• 7681-65-4 copper(I) iodide 

Relevant articles and documents

Copper-catalyzed highly regioselective 2-aryloxylation of 2,x-dihalopyridines

2,x-Dihalopyridines reacted with phenols catalyzed by CuI/TMEDA in the presence of Cs2CO3 in DMSO at 110 °C under nitrogen atmosphere for 24 h to afford 2-aryloxypyridines in good to high yields except p-nitrophenol. To expand this methodology, a vanilloid receptor ligand used in treatments was prepared in good yield. This method has potential utility in the synthesis of pharmaceuticals, agrochemicals and even natural products.