5454-06-8

Basic information

• Product Name: 2-(3-phenylpropyl)propanedioic acid
• Synonyms: 2-(3-phenylpropyl)propanedioic acid
• CAS NO: 5454-06-8
• Molecular Formula: C₁₂H₁₄O₄
• Molecular Weight: 222.24
• Mol File: 5454-06-8.mol

Chemical Properties

• Boiling Point: 455.9°Cat760mmHg
• Flash Point: 243.6°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 4.2E-09mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(3-phenylpropyl)propanedioic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-phenylpropyl)propanedioic acid(5454-06-8)
• EPA Substance Registry System: 2-(3-phenylpropyl)propanedioic acid(5454-06-8)

Safety Data

• Hazardous Substances Data: 5454-06-8(Hazardous Substances Data)

Usage

Type of compound

dicarboxylic acid

Functional groups

two carboxyl groups (COOH) and a phenylpropyl group (C6H5-CH2-CH(CH3)-)

Usage

building block for the production of pharmaceuticals and agrochemicals, potential medicinal properties (anti-cancer and anti-inflammatory effects), potential additive for enhancing the performance of polymers and plastic materials.

InChI:InChI=1/C12H14O4/c13-11(14)10(12(15)16)8-4-7-9-5-2-1-3-6-9/h1-3,5-6,10H,4,7-8H2,(H,13,14)(H,15,16)

Upstream product

• 16900-64-4 4-phenylbut-1-en-3-yne-1,1-dicarboxylic acid 
• 34795-56-7 2-cyano-5-phenyl-pentanoic acid ethyl ester 
• 14371-10-9 (E)-3-phenylpropenal 
• 4358-53-6 Racem-1-Benzyl-cyclopropan-dicarbonsaeure-(2.2) 
• 28028-86-6 (E)-2-(3-phenylallylidene)malonic acid 
• 26395-09-5 diethyl 2-(3-phenylpropyl)malonate 

Downstream Products

• 2270-20-4 5-Phenylpentanoic acid 
• 84299-13-8 bromo-(3-phenyl-propyl)-malonic acid 
• 861803-26-1 dimethylaminomethyl-(3-phenyl-propyl)-malonic acid 
• 32060-78-9 1,2-diphenyl-4-(3-phenyl-propyl)-pyrazolidine-3,5-dione 
• 84299-75-2 2-bromo-5-phenyl-valeric acid 
• 34993-02-7 2-(R)-amino-5-phenylpentanoic acid 
• 116112-43-7 2-acetylthiomethyl-5-phenylpentanoic acid 
• 78574-19-3 2-methylene-5-phenylvaleric acid chloride 
• 109398-68-7 toluene-4-sulphonic acid 5-phenyl-pentyl ester 
• 7508-26-1 (5-phenyl-pentyl)-malonic acid 
• 1030-68-8 2-Cyan-7-phenyl-heptansaeure-aethylester 
• 107416-06-8 7-phenyl-heptanoic acid amide 
• 27346-09-4 α-Chloro-δ-phenyl-valeriansaeureaethylester 
• 40228-90-8 7-phenylheptanoic acid 

Relevant articles and documents

Impact of the carbon chain length of novel palladium(ll) Complexes on interaction with DNA and cytotoxic activity

A series of Pd(II) complexes with a benzenealkyl dicarboxlate chain, with the formulas [Pd(Ln)(bipy)].mH2O (bipy = 2,2'-bipyridine, complex 1: L1 = phenylmalonate, m = 2.5; complex 2: L2 = benzylmalonate, m = 1; complex 3: L3 = phenethylmatonate, m = 2; complex 4: L4 = phenylpropylmalonate, m = 5), have been prepared in an attempt to correlate factors about the carbon chain of the compounds with DNA binding and cytotoxic activity. The binding of complexes with fish sperm DNA (FS-DNA) was carried out by UV absorption and fluorescence spectra. A gel electrophoresis assay demonstrated the ability of the complexes to cleave the pBR322 plasmid DNA. The cytotoxic effects of these complexes were examined on four cancer cell lines, HeLa, Hep-G2, KB, and AGZY-83a. The four complexes exhibited cytotoxic specificity and a significant cancer cell inhibitory rate. An apparent dependence of DNAbinding properties and cytotoxicity on the carbon chain length was obtained: the longer the carbon chain length, the higher the efficiency of DNA-binding and the greater the cytotoxicity. 2010 American Chemical Society.

beta -thiopropionyl-aminoacid derivatives and their use as beta -lactamase inhibitors

PCT No. PCT/EP97/00516 Sec. 371 Date Jan. 13, 1999 Sec. 102(e) Date Jan. 13, 1999 PCT Filed Feb. 3, 1997 PCT Pub. No. WO97/30027 PCT Pub. Date Aug. 21, 1997A method of treatment of bacterial infections in humans or animals which comprises administering, in combination with a beta -lactam antibiotic, a therapeutically effective amount of an amino acid derivative of Formula (I) or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: R is hydrogen, a salt forming cation or an in vivo hydrolysable ester-forming group; R1 is hydrogen, (C1-6)alkyl optionally substituted by up to three halogen atoms or by a mercapto, (C1-6)alkoxy, hydroxy, amino, nitro, carboxy, (C1-6)alkylcarbonyloxy, (C1-6)alkoxycarbonyl, formyl or (C1-6)alkylcarbonyl group, (C3-7)cycloalkyl, (C3-7)cycloalkyl(C2-6)alkyl, (C2-6)alkenyl, (C2-6)alkynyl, aryl, aryl(C1-6)alkyl, heterocyclyl or heterocyclyl(C1-6)alkyl; R2 is hydrogen, (C1-6)alkyl or aryl(C1-6)alkyl; R3 is hydrogen, (C1-6)alkyl optionally substituted by up to three halogen atoms, (C3-7)cycloalkyl, fused aryl(C3-7)cycloalkyl, (C3-7)cycloalkyl(C2-6)alkyl, (C2-6)alkenyl, (C2-6)alkynyl, aryl, aryl-(CHR10)m-X-(CHR11)n, heterocyclyl or heterocyclyl-(CHR10)m-X-(CHR11)n, where m is 0 to 3, n is 1 to 3, each R10 and R11 is independently hydrogen or (C1-4)alkyl and X is O, S(O)x where x is 0-2, or a bond; R4 is hydrogen, or an in vivo hydrolysable acyl group; and R5 and R6 are independently hydrogen and (C1-6)alkyl or together represent (CH2)p where p is 2 to 5. Some compounds are claimed per se.