78574-19-3

Upstream product

• 78574-20-6 2-methylene-5-phenylpentanoic acid 
• 27356-88-3 ethyl 2-methylene-5-phenylpentanoate 
• 5454-06-8 3-phenylpropylmalonic acid 
• 26395-09-5 diethyl 2-(3-phenylpropyl)malonate 
• 637-59-2 1-Bromo-3-phenylpropane 

Downstream Products

• 80091-10-7 N-ethyl-2-methylene-5-phenylpentanamide 
• 80091-11-8 N,N-diethyl-2-methylene-5-phenylpentanamide 
• 80091-09-4 2-methylene-5-phenylpentanamide 

Relevant academic research and scientific papers

Ni-Catalyzed enantioselective reductive arylcyanation/cyclization of: N -(2-iodo-aryl) acrylamide

A Ni/(S,S)-BDPP-catalyzed intramolecular Heck cyclization of N-(2-iodo-aryl) acrylamide with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. We found that utilizing such an electrophilic cyanation reagent cou

Stereoselective synthesis of Z-vinylsilanes via palladium-catalyzed direct intermolecular silylation of C(sp2)-H bonds

An efficient and convenient palladium-catalyzed direct intermolecular silylation of C(sp2)-H bonds by using disilanes as the silicon source with the assistance of a readily removable bidentate directing group is reported. This strategy provided a regio- and stereoselective protocol for exclusive synthesis of Z-vinylsilanes with reasonable to excellent yields and good functional group compatibility. Silylation of the isolated palladacycle intermediate revealed the Z-stereoselective pathway. Moreover, the practicality and effectiveness of this method were illustrated by a gram-scale experiment and further functionalization of the silylation product.

Synthesis and Hypoglycemic Activity of Phenylalkyloxiranecarboxylic Acid Derivatives

A series of new 2-(phenylalkyl)oxirane-2-carboxylic acids has been synthesized and studied for its effects on the concentration of blood glucose.Most of the compounds exhibit remarkable blood glucose lowering activities in fasted rats.Structure-activity s

Substituted oxiranecarboxylic acids, their use and medicaments containing them

Substituted oxiranecarboxylic acids of the formula STR1 wherein R1 denotes a hydrogen atom (--H), a halogen atom, a hydroxylroup, a lower alkyl group, a lower alkoxy group or a trifluoromethyl group, R2 has one of the meanings of Rs