5454-19-3Relevant academic research and scientific papers
Method for preparing organic carboxylic ester through combined catalysis of aryl bidentate phosphine ligand
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Paragraph 0039, (2020/05/29)
The invention discloses a method for preparing organic carboxylic ester by combined catalysis of an aryl bidentate phosphine ligand. The method comprises the following steps: under the action of a palladium compound/aryl bidentate phosphine ligand/acidic additive combined catalyst, carrying out a hydrogen esterification reaction on terminal olefin, carbon monoxide and alcohol so as to generate theorganic carboxylic ester with one more carbon than olefin. According to the invention, by adoption of the palladium compound/aryl bidentate phosphine ligand/acidic additive combined catalyst, good catalytic activity and selectivity for the hydrogen esterification reaction of the olefin are achieved, and olefin carbonylation to synthesize organic carboxylic ester can be efficiently catalyzed. Thearyl bidentate phosphine ligand has a rigid skeleton structure of a rigid ligand and the flexibility of a flexible ligand, so the aryl bidentate phosphine ligand has proper flexibility due to the characteristic that the aryl bidentate phosphine ligand is soft and rigid, and a most favorable coordination mode and a stable active structure in space are favorably formed. In addition, the aryl bidentate phosphine ligand has the advantages of high stability, simple and convenient synthesis method and the like; and a novel industrial technology is provided for production of organic carboxylate compounds.
Efficient flow fischer esterification of carboxylic acids with alcohols using sulfonic acid-functionalized silica as supported catalyst
Furuta, Akihiro,Fukuyama, Takahide,Ryu, Ilhyong
, p. 607 - 612 (2017/06/19)
Flow Fischer esterification of carboxylic acids using hydroxy-substituted sulfonic acid-functionalized silica (HOSAS) packed into a stainless steel column reactor was investigated. HO-SAS well catalyzed flow esterification of long chain carboxylic acids with methanol within 3min of residence time at 110°C, and the methyl esters were quantitatively obtained. The flow esterification protocol was applied to the synthesis of a variety of esters (19 examples) and scalable synthesis was also successful.
Cobalt(II)-catalyzed direct acetylation of alcohols with acetic acid
Velusamy, Subbarayan,Borpuzari, Sarbani,Punniyamurthy
, p. 2011 - 2015 (2007/10/03)
Cobalt(II) chloride hexahydrate (CoCl2·6H2O) efficiently catalyzes the acetylation of alcohols with AcOH in high yields. This protocol is also effective with other carboxylic acids, trifluoroacetic acid, propanoic acid, phenylacetic acid and benzoic acid, affording the corresponding acylated products in moderate to good yields. Removal of water is not necessary in these reactions. The catalyst can be filtered and recycled without loss of activity.
Facile acetylation of alcohols, ethers and ketals with catalytic FeCl3 in AcOH
Sharma,Mahalingam,Nagarajan,Ilangovan,Radhakrishna, Palakodety
, p. 1200 - 1202 (2007/10/03)
A simple and efficient protocol for the conversion of alcohols, ethers and ketals to acetates using catalytic FeCl3(5mol%) in AcOH, or AcOH (3eq) in CH2Cl2 in very high yield is reported. A variety of other acids such as CF3CO2H, HCO2H, CH2=CHCO2H, CH3CH2CO2H, CH3(CH2)2CO2H have also been utilised for the acylation of alcohols successfully.
Carboxylic acids supported on silica: A smooth acylating agent for alcohols
Da Graca Nascimento, Maria,Zanotto, Sandra Patricia,Scremin, Marivania,Rezende, Marcos Caroli
, p. 2715 - 2721 (2007/10/03)
An alternative procedure for the esterification of alcohols by short-chain carboxylic acids supported on silica is presented.
