54540-94-2Relevant academic research and scientific papers
Br?nsted-Acid-Promoted Selective C2–N1 Ring-Expansion Reaction of Indoles toward Cyclopenta[b]quinolines
Cheng, Lu,Li, Yanzhong,Wang, Chengyu,Yang, Yajie,Yin, Liqiang,Zhu, Yilin
, p. 966 - 970 (2022/02/05)
A novel Br?nsted-acid-promoted selective C2–N1 ring-expansion reaction of indoles has been developed that provides a rapid and efficient protocol for the preparation of fused quinolines. A variety of corresponding quinolines were obtained in high yields. Controlled experiments revealed that C2-spiroindolenines might be intermediates of this C2–N1 ring-expansion reaction. The notable advantages of this process include excellent yields, good functional group tolerance, and operational simplicity.
