5456-21-3Relevant academic research and scientific papers
A 2-mercapto-5-methyl -1, 3, 4-thiadiazole method for the preparation of
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Paragraph 0023-0026, (2017/03/14)
The invention relates to a preparation method of 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole. The preparation method of the 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole, provided by the invention, comprises the following steps of: (1) placing the weighted hydrazine hydrate and ammonium hydroxide into a reaction vessel to be uniformly mixed, dropwise adding carbon disulfide at low temperature, after the dropwise adding operation is ended, stirring and preserving the heat to obtain a water solution of diazanyl dithiocarbamate; (2) adding acetonitrile into the reaction vessel, reacting while stirring, heating, stirring, preserving heat and reflowing to obtain a water solution of 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole aluminum salt; and (3) when the reaction vessel in the step (2) is cooled to be below 40 DEG C, dropwise adding hydrochloric acid for acidifying to obtain a 2-methyl-5-sulfydryl-1, 3, 4-thiadiazole suspension, filtering and washing to obtain milk white crystal powder, namely a crude product of the 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole, and then, purifying and drying the crude product to obtain white crystal powder, namely the 2-sulfydryl-5-methyl-1, 3, 4-thiadiazole. The preparation method has the characteristics of simplicity and convenience in process operation, short reaction time, low production cost and few wastes and pollutants.
