5456-63-3

Basic information

• Product Name: TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE
• Synonyms: AMINOCYCLOHEXANOL(TRANS-2) HCL;TRANS- AMINOCYCLOHEXANOL HYDROCHLORIDE;TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE;TRANS-2-HYDROXY-1-CYCLOHEXYLAMINE HYDROCHLORIDE;TRNS-2-HYDROXYCYCLOHEXYLAMINE HYDROCHLORIDE;AminocyclohexanolHCl,trans-2-;Cyclohexanol, 2-amino-, hydrochloride, (1R,2R)-rel-;trans-2-hydroxycyclohexylamine hydrochloride
• CAS NO: 5456-63-3
• Molecular Formula: C₆H₁₃NO*ClH
• Molecular Weight: 151.63
• Product Categories: Amino Alcohols;Organic Building Blocks;Oxygen Compounds
• Mol File: 5456-63-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 172-175 °C(lit.)
• Boiling Point: 241.2 °C at 760 mmHg
• Flash Point: 99.7 °C
• Appearance: White or beige to light brown/Crystalline Powder
• Density: 1.037 g/cm³
• Vapor Pressure: 0.0773mmHg at 25°C
• Refractive Index: 1.502
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: soluble25mg/mL, clear, colorless (1N acetic acid in methanol)
• Sensitive: Hygroscopic
• CAS DataBase Reference: TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE(5456-63-3)
• EPA Substance Registry System: TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE(5456-63-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 5456-63-3(Hazardous Substances Data)

Usage

Chemical Properties

white or beige to light brown crystalline powder

Uses

NSC 21550 is used in preparation of Benzoxazinone derivatives.

InChI:InChI=1/C6H13NO/c7-5-3-1-2-4-6(5)8/h5-6,8H,1-4,7H2/t5-,6-/m0/s1

Upstream product

• 1541-26-0 2-cyclohex-2-enyl-isoindole-1,3-dione 
• 83152-89-0 trans-2-isocyano-2-methylcyclohexanol 
• 83152-97-0 trans-2-isocyano-1-cyclohexanol 
• 40571-86-6 rac-(1R,2R)-2-(benzylamino)cyclohexanol 
• 148202-10-2 (+/-)-trans-2-benzylidenamino-cyclohexanol 
• 106729-82-2 (1R,2R,6R)-2-Bromo-6-[3H-isobenzofuran-(1Z)-ylideneamino]-cyclohexanol 
• 822-67-3 Cyclohex-2-enol 
• 106729-82-2 1,2-trans-1,6-cis-2-bromo-6-(1,3-dihydroisobenzofuran-1-ylideneamino)-cyclohexanol 
• 106729-81-1 o-cyclohex-2-enylcarbamoylbenzyl alcohol 
• 116429-76-6 ((3aS,4S,7aS)-4-Bromo-2-ethoxy-2-phenyl-hexahydro-benzooxazol-3-yl)-phenyl-methanone 
• 106729-73-1 cyclohex-2-enyl-N-benzoylbenzimidate 
• 106729-74-2 1,2-cis-2,3-trans-2-benzamido-3-bromocyclohexyl benzoate 
• 3413-44-3 (R)-2-cyclohexen-1-ol 
• 106729-83-3 (1S,2R)-2-[3H-Isobenzofuran-(1Z)-ylideneamino]-cyclohexanol 

Downstream Products

• 38436-56-5 cis-β-Hydroxycyclohexyl-trimethylammonium-iodid 
• 38382-30-8 trans-(2-(phenylamino)cyclohexanol) 

Relevant articles and documents

Improved Procedure for the Selective N-Debenzylation of Benzylamines by Diisopropyl Azodicarboxylate

The selective deprotection of N-benzyl group was achieved in the presence of azido, O-benzyl, and N-tosyl groups in reactions of benzylamines derived from 1,6-anhydro-β-D-glucopyranose with diisopropyl azodicarboxylate (DIAD) in THF. The key role of this solvent and the reaction pathway are presented together with proven reaction intermediates.

SYNTHESIS OF (L)-DAUNOSAMINE AND RELATED AMINO SUGARS

1-(2-Furyl)ethanol (6) has been converted into methyl (+/-)-daunosaminide (1) and methyl (+/-)-ristosaminide (3) by use of an intramolecular cyclisation of a trichloroacetimidate group. (+/-)-Daunosamine (1) has been obtained more directly from the alcohol (10) by use of a modified Mitsunobu reaction; the scope of the latter reaction has been explored using cyclohex-2-en-1-ol as a model substrate.Asymmetric reduction of 2-acetylfuran (5) has given (S)-1-(2-furyl)ethanol (46) in good enantiomeric excess, thus providing a short route to the L-enantiomers of the amino sugars (1), (2), and (3) from a cheap, non-carbohydrate precursor.

Opening of Epoxides with Trimethylsilyl Cyanide To Produce β-Hydroxy Isonitriles. A General Synthesis of Oxazolines and β-Amino Alcohols

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