121282-70-0

Basic information

• Product Name: Boc-(+/-)-trans-2-aminocyclohexanol
• Synonyms: trans-N-Boc-2-aminocyclohexanol;tert-butyl (1R,2R)-2-hydroxycyclohexylcarbamate;1R,2R-Boc-2-aMinocyclohexanol;tert-Butyl (trans-2-hydroxycyclohexyl)carbaMate;tert-butyl (2-hydroxycyclohexyl)carbaMate;Trans-tert-butyl 2-hydroxycyclohexyl)carbaMate;tert-Butyl (trans-2-hydroxycyclohexyl)
• CAS NO: 121282-70-0
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.29
• Mol File: 121282-70-0.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 337.7±31.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.11±0.40(Predicted)
• CAS DataBase Reference: Boc-(+/-)-trans-2-aminocyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-(+/-)-trans-2-aminocyclohexanol(121282-70-0)
• EPA Substance Registry System: Boc-(+/-)-trans-2-aminocyclohexanol(121282-70-0)

Safety Data

• Hazardous Substances Data: 121282-70-0(Hazardous Substances Data)

Usage

Description

Boc-(+/-)-trans-2-aminocyclohexanol, also known as tert-Butyl (2-Hydroxycyclohexyl)carbamate, is an organic compound that serves as a crucial reagent in the synthesis of various chemical compounds. It is characterized by its ability to facilitate the conversion of nitro compounds into N-aryl acetamides, which are essential in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
Boc-(+/-)-trans-2-aminocyclohexanol is used as a synthetic reagent for the preparation of N-aryl acetamides from the corresponding nitro compounds. This application is significant because N-aryl acetamides are key intermediates in the synthesis of various pharmaceutical compounds, including those with analgesic, anti-inflammatory, and antimicrobial properties.
Used in Chemical Industry:
In the chemical industry, Boc-(+/-)-trans-2-aminocyclohexanol is utilized as a versatile reagent for the synthesis of a wide range of organic compounds. Its ability to convert nitro compounds into N-aryl acetamides makes it a valuable tool in the development of new materials and chemicals with diverse applications, such as in the fields of agriculture, plastics, and coatings.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 5456-63-3 trans-2-aminocyclohexanol hydrochloride 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 98454-42-3 (±)-trans-2-(benzyloxy)cyclohexanamine 
• 85761-38-2 (+/-)-trans-2-benzyloxycyclohexan-1-ol 
• 931-15-7 (1S,2S)-trans-2-aminocyclohexanol 
• 108-05-4 vinyl acetate 
• 121282-70-0 (+/-)-trans-1-hydroxy-2-tert-butoxycarbonylamino-cyclohexane 
• 216394-07-9 1-(S)-trans-(S)-2-phenylmethoxycyclohexylamine 
• 34619-03-9 tert-butyldicarbonate 
• 1392837-23-8 (1S,6S)-6-aminocyclohex-3-en-1-ol 
• 1392837-28-3 (1S,6S)-6-(diallylamino)cyclohex-3-en-1-ol 
• 1392837-24-9 tert-butyl (1S,6S)-N-[6-(hydroxy)cyclohex-3-enyl]carbamate 
• 13374-30-6 (1S,2S)-2-hydroxycyclohexylamine hydrochloride 

Downstream Products

• 121282-70-0 (1S,2S)-2-tert-Butoxycarbonylamino-1-cyclohexanol 
• 931-16-8 (+/-)-trans-2-aminocyclohexanol 
• 365996-28-7 (1S,2S)-2-(tert-butoxycarbonylamino)cyclohexyl methanesulfonate 
• 214679-17-1 (1S,2R)-(-)-1-tert-butoxycarbonylaminocyclohexan-2-ol 
• 1269650-09-0 (1R,2S)-2-(tert-butoxycarbonylamino)cyclohexyl 4-nitrobenzoate 
• 1370261-95-2 tert-butyl (1S,2R)-2-(4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-5-carbamoylpyrimidin-2-ylamino)cyclohexylcarbamate 
• 1370261-98-5 4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1R, 2S)-2-aminocyclohexylamino)pyrimidine-5-carboxamide acetic acid salt 
• 1332702-03-0 tert-butyl ((1S,2S)-2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)cyclohexyl)carbamate 
• 291533-10-3 2-(tert-butoxycarbonylamino)cyclohexanone 
• 80860-42-0 tert-butyl 6-oxohexylcarbamate 
• 1354251-15-2 tert-butyl ((1S,2R)-2-((6-chloro-5-cyano-3-fluoropyridin-2-yl)amino)cyclohexyl)carbamate 
• 1123685-32-4 tert-butyl [(1S,2R)-2-(phthalimido)cyclohexyl]-carbamate 
• 603128-72-9 N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]-N-(thymin-1-ylacetyl)glycine ethyl ester 
• 680591-66-6 N-[(2S)-tert-butyloxycarbonylaminocyclohex-(1R)-yl]-N-(chloroacetyl)glycine ethyl ester 

Relevant articles and documents

A new facile method for the chemoselective reductive transformation of azides to N-(tert-butoxycarbonyl)amines

A new chemoselective procedure for the reductive transformation of organic azides to the corresponding N-(tert-butoxycarbonyl)amino derivatives using triethylsilane and di-tert-butyl dicarbonate in the presence of a catalytic amount of 20% Degussa Pd(OH)

COMPOUNDS, COMPOSITIONS AND METHODS FOR SYNTHESIS

The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis. In some embodiments, the present disclosure provides compounds useful as chiral auxiliaries. In some embodiments, the present disclosure provides reagents and methods for oligonucleotide synthesis. In some embodiments, the present disclosure provides reagents and methods for chirally controlled preparation of oligonucleotides. In some embodiments, technologies of the present disclosure are particularly useful for constructing challenging internucleotidic linkages, providing high yields and stereoselectivity.

CYCLOHEXANEDIAMINE COMPOUNDS AND METHODS FOR THEIR PREPARATION

The present invention provides processes for the preparation of cyclohexanediamine compounds of formula Ia and intermediates thereof. The compounds are useful as Syk kinase inhibitors and in various pharmaceutical compositions, and particularly useful for treating conditions mediated at least in part by Syk kinase activity.