54567-07-6Relevant academic research and scientific papers
Phenolic structure and colour in Mannich reaction products
Tyman, John H.P.,Patel, Mahesh
, p. 34 - 37 (2008/02/02)
Mannich reactions have been carried out with a variety of model alkylphenols and dimethylamine, methylamine, and diethylenetriamine to trace the origin of persistent coloured products occurring in related reactions with pentadeca(e)nylphenol and 4-tert-alkylphenols. It was found to be attributable to the presence of resorcinolic impurities.
ENHANCEMENT OF THE RATE OF MANNICH REACTIONS IN AQUEOUS MEDIA
Tychopoulos, V.,Tyman, J. H. P.
, p. 1401 - 1410 (2007/10/02)
The rate of Mannich reaction of phenols and of ketones with secondary amines is greatly increased in aqueous compared with alcoholic or hydrocarbon solvents.Two phase system are present and a phase transfer catalysis may be operative.With phenols and excess co-reactants the proucts are mono- or isomeric disubstituted dialkylaminomethyl derivatives dependent upon the reaction time.
