54584-33-7Relevant academic research and scientific papers
A dual role for acetohydrazide in Pd-catalyzed controlled C(sp3)-H acetoxylation of aldehydes
Bai, Chaolumen,Bao, Yong-Sheng,Chen, Juan,Liu, Dan,Tong, Xingwen
, p. 12192 - 12196 (2020)
The palladium catalyzed aldehyde directed acetoxylation of C(sp3)-H bonds was realized by a transient directing group approach for the first time. Crucial to the successful outcome of this reaction is the dual role of acetohydrazide as a directing group for the catalytic C(sp3)-H activation process and as a protecting group for the CHO functional group. The applicable methodology exhibits good functional group tolerance and occurs readily under mild conditions.
