54584-49-5

Basic information

• Product Name: 3-Pyridinecarboxylic acid, 2-[(phenylamino)thioxomethyl]hydrazide
• Synonyms: 1-nicotinoyl-4-phenyl thiosemicarbazide;1-nicotinoyl-4-phenyl-thiosemicarbazide
• CAS NO: 54584-49-5
• Molecular Formula: C13H12N4OS
• Molecular Weight: 272.33
• Mol File: 54584-49-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxylic acid, 2-[(phenylamino)thioxomethyl]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxylic acid, 2-[(phenylamino)thioxomethyl]hydrazide(54584-49-5)
• EPA Substance Registry System: 3-Pyridinecarboxylic acid, 2-[(phenylamino)thioxomethyl]hydrazide(54584-49-5)

Safety Data

• Hazardous Substances Data: 54584-49-5(Hazardous Substances Data)

Upstream product

• 553-53-7 Nicotinic acid hydrazide 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 500119-14-2 3-[5-(benzylsulfanyl)-4-phenyl-4H-1,2,4-triazol-3-yl]-pyridine 
• 57600-03-0 4-phenyl-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol 
• 1421958-34-0 Hg(en)(pptt)2 

Relevant articles and documents

Design, Synthesis and Antibacterial Evaluation of 1-[(1R,2S)-2-Fluorocyclopropyl]ciprofloxacin-1,2,4-triazole-5(4H)-thione Hybrids

A new class of 1-[(1R,2S)-2-fluorocyclopropyl]ciprofloxacin (CPFX)-1,2,4-triazole-5(4H)-thione hybrids 6a?–?6o was designed, synthesized and evaluated for their in?vitro antibacterial activities against a panel of clinically important drug-sensitive and d

Synthesis and biological evaluation of 3-amino-1,2,4-triazole derivatives as potential anticancer compounds

Two series of compounds carrying 3-amino-1,2,4-triazole scaffold were synthesized and evaluated for their anticancer activity against a panel of cancer cell lines using XTT assay. The 1,2,4-triazole synthesis was revisited for the first series of pyridyl derivatives. The biological results revealed the efficiency of the 3-amino-1,2,4-triazole core that could not be replaced and a clear beneficial effect of a 3-bromophenylamino moiety in position 3 of the triazole for both series (compounds 2.6 and 4.6) on several cell lines tested. Moreover, our results point out an antiangiogenic activity of these compounds. Overall, the 5-aryl-3-phenylamino-1,2,4-triazole structure has promising dual anticancer activity.

Synthetic nicotinic/isonicotinic thiosemicarbazides: In vitro urease inhibitory activities and molecular docking studies

Nicotinic and isonicotinic thiosemicarbazide or hydrazine carbothioamides 3–27 were synthesized and the structures of synthetic compounds were elucidated by various spectroscopic techniques such as EI-MS, 1H-, and 13C NMR. Synthetic derivatives were evaluated for their urease inhibitory activity which revealed that except few all derivatives demonstrated excellent inhibition in the range of IC50 values of 1.21–51.42 μM as compared to the standard thiourea (IC50 = 21.25 ± 0.13 μM). Among the twenty-five synthetic derivatives nineteen 1–5, 7, 8, 10, 12, 14–18, 20–22, 24–27 were found to be more active showing IC50 values between 1.13 and 19.74 μM showing superior activity than the standard. Limited structure-activity relationship demonstrated that the positions of substituent as well as position of nitrogen in pyridine ring are very important for inhibitory activity of this class of compound. To verify these interpretations, in silico study was also performed. A good correlation was obtained between the biological evaluation of active compounds and docking study.