545882-78-8Relevant academic research and scientific papers
Synthesis of 1-amino-3-[(dihydroxyboryl)methyl]-cyclobutanecarboxylic acid as a potential therapy agent
Kabalka, George W.,Yao, Min-Liang
, p. 8280 - 8286 (2004)
A novel boronated aminocyclobutanecarboxylic acid (1) was synthesized for potential use in boron neutron capture therapy. Starting from the readily available 3-(bromomethyl)cyclobutanone ketal (4), several synthetic routes to 1 were evaluated. After sever
An efficient route to 3-substituted cyclobutanone derivatives
Kabalka, George W.,Yao, Min-Liang
, p. 1879 - 1881 (2007/10/03)
An efficient route to 3-(hydroxymethyl)cyclobutanone acetals via a [2+2] cycloaddition reaction is reported. The dramatic effect of different diol acetals on benzyl deprotection is discussed. Efficient synthesis of two synthetically useful intermediates, 3-methylenecyclobutanone acetal and 3-(bromomethyl)cyclobutanone, are provided.
