545882-54-0

Upstream product

• 6920-22-5 Hexane-1,2-diol 
• 172324-67-3 3-benzyloxymethyl-cyclobutanone 
• 172324-66-2 3-(benzyloxymethyl)-2,2-dichlorocyclobutanone 
• 14593-43-2 benzyl allyl ether 

Downstream Products

• 654061-31-1 toluene-4-sulfonic acid 6-butyl-5,8-dioxa-spiro[3.4]oct-2-ylmethyl ester 
• 811438-51-4 3-(phenylselanylmethyl)cyclobutanone 
• 545882-78-8 6-butyl-2-methylene-5,8-dioxa-spiro[3.4]octane 
• 463961-43-5 3-(bromomethyl)cyclobutanone 
• 811438-55-8 C₁₃H₁₄N₂O₃Se 
• 811438-50-3 6-butyl-2-phenylselanylmethyl-5,8-dioxa-spiro[3.4]octane 
• 811438-53-6 2-phenylselanylmethyl-5,7-diaza-spiro[3.4]octane-6,8-dione 
• 811438-57-0 6-butyl-2-phenylsulfanylmethyl-5,8-dioxa-spiro[3.4]octane 

Relevant academic research and scientific papers

Synthesis of 1-amino-3-[(dihydroxyboryl)methyl]-cyclobutanecarboxylic acid as a potential therapy agent

A novel boronated aminocyclobutanecarboxylic acid (1) was synthesized for potential use in boron neutron capture therapy. Starting from the readily available 3-(bromomethyl)cyclobutanone ketal (4), several synthetic routes to 1 were evaluated. After sever

An efficient route to 3-substituted cyclobutanone derivatives

An efficient route to 3-(hydroxymethyl)cyclobutanone acetals via a [2+2] cycloaddition reaction is reported. The dramatic effect of different diol acetals on benzyl deprotection is discussed. Efficient synthesis of two synthetically useful intermediates, 3-methylenecyclobutanone acetal and 3-(bromomethyl)cyclobutanone, are provided.

Synthesis of a Potential Boron Neutron Capture Therapy Agent: 1-Amino-cyclobutane-1-carboxylic Acid Bearing a Butylboronic Acid Side Chain

A novel boronated aminocyclobutanecarboxylic acid was synthesized for potential use in neutron capture therapy. The synthesis involves the preparation of tosylate 5, which was then converted to an amino acid using Bucherer-Strecker methodology. The molecu