54592-00-6Relevant academic research and scientific papers
MODULATORS OF STIMULATOR OF INTERFERON GENES (STING)
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Page/Page column 66-67, (2020/01/08)
The present invention relates to compounds of formula (I) and salts, stereoisomers, tautomers or N-oxides thereof that are useful as modulators of STING (Stimulator of Interferon Genes). The present invention further relates to the compounds of formula (I) for use as a medicament and to a pharmaceutical composition comprising said compounds.
Synthesis of 3-(substituted methyl)-2-phenyl-4H-1-benzothiopyran-4-ones
Nakazumi,Ueyama,Sonoda,Kitao
, p. 2323 - 2324 (2007/10/02)
Reaction of 2-phenyl-4H-1-benzothiopyran-4-ones and related compounds with chloromethyl methyl ether and fuming sulfuric acid gave mainly the 3-chloromethyl compound, whereas chloromethylation of methoxy-substituted thioflavones took place at another position or gave the tris(chloromethyl) compound. 3-(Chloromethyl)thioflavone could be easily converted into various 3-(substituted methyl)thioflavones which showed significant antimicrobial activity against Trichophytons.
