546-43-0 Usage
Description
The allergen eudesmanolide sesquiterpene lactone was
isolated from elecampane (Inula helenium L.). With
dehydrocostuslactone and costunolide, it is a component
of the (sesquiterpene) lactone-mix, used to detect
sensitization to Compositae.
Chemical Properties
Crystalline powder
Uses
Different sources of media describe the Uses of 546-43-0 differently. You can refer to the following data:
1. anthelmintic, antibacterial, antineoplastic
2. Alantolactone is sesquiterpene lactone that possesses anti-inflammatory property. Alantolactone have been studied to be developed as a novel agent against human liver cancer.
3. Alantolactone has been used:in cell viability assayto examine the percentage of multicentrosomal mitosis in low and high passage human embryonic stem cells (hESC)in assessment of degranulation
Definition
ChEBI: A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biochem/physiol Actions
Alantolactone is a sesquiterpene lactone disrupts the Cripto-1/ActRII complexes, resulting in an induction of activin/SMAD3 signaling. Alantolactone inhibits proliferation in cancer cells with no affect on normal cells.
Contact allergens
The allergen eudesmanolide sesquiterpene lactone was
isolated from elecampane (Inula helenium L.). With
dehydrocostuslactone and costunolide, it is a component
of the (sesquiterpene) lactone mix used to detect
sensitization to Compositae-Asteraceae.
Check Digit Verification of cas no
The CAS Registry Mumber 546-43-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,4 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 546-43:
(5*5)+(4*4)+(3*6)+(2*4)+(1*3)=70
70 % 10 = 0
So 546-43-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h7,9,11,13H,2,4-6,8H2,1,3H3/t9-,11+,13+,15+/m1/s1
546-43-0Relevant articles and documents
An Annelation Approach to the Synthesis of Eudesmane and Elemane Sesquiterpene Lactones. Total Synthesis of dl-Dihydrocallitrisin, dl-7,8-Epialantolactone, dl-7,8-Epiisoalantolactone, and dl-Atractylon
Schultz, Arthur G.,Godfrey, Jollie D.
, p. 2414 - 2428 (2007/10/02)
An annelation approach to the synthesis of eudesmane sesquiterpenes is described.The 1,6-annelation reagent α-carbomethoxy-β-methyl-γ-methylidene-Δα,β-butenolide (1) is used to construct the linear tricyclic lactone 2,5,6,7,8,8a,9,9aβ-octahydro-8aβ-methyl-2-oxonaphthofuran-3-carboxylic acid methyl ester (2).The conversion of 2 to dl-dihydrocallitrisin (3), dl-7,8-epialantolactone (4), dl-7,8-epiisoalantolactone (5), and dl-atractylon (6) is detailed.Studies directed toward synthesis of the elemane sesquiterpene lactones vernomenin and vernolepin also are presented.
