54605-79-7Relevant academic research and scientific papers
Harnessing in Situ Radical Oxygenation: Copper-Catalyzed Interrupted Azirine-Alkyne Ring-Expansion Reaction for the Synthesis of Pyrrolones
Sujatha, Chandragiri,Nallagangula, Madhu,Namitharan, Kayambu
, p. 4219 - 4223 (2021)
Here we report a novel interrupted azirine-alkyne ring-expansion reaction with molecular oxygen for the direct synthesis of highly functionalized pyrrolones enabled by copper catalysis. Mechanistic investigations indicate that the present three-component reaction proceeds via two copper-catalyzed sequential reactions, an azirine-ring-opening alkynylation and an amine-directed radical oxygenation, leading to the formation of interesting pyrrolone structures under mild conditions.
