54606-49-4

Usage

Uses

Used in Molecular Diffusion Studies:
3-(AMINOMETHYL)-PROXYL is used as a spin label for studying molecular diffusion in biological systems, such as its application in studying the diffusion of molecules into horse spleen ferritin. This helps researchers gain insights into the dynamics and interactions of molecules within complex biological environments.
Used as a Radioprotector:
3-(AMINOMETHYL)-PROXYL is used as an effective nonthiol radioprotector, providing protection against radiation-induced damage in various applications, such as medical and industrial settings where exposure to radiation is a concern.
Used in Pharmacological Studies:
3-(AMINOMETHYL)-PROXYL is used in pharmacological studies of myeloperoxidase-mediated hypochlorous acid production inhibition. This helps in understanding the role of this enzyme in various biological processes and its potential as a therapeutic target for certain diseases.
Used in Chemical Reactions:
3-(AMINOMETHYL)-PROXYL is involved in reduction reactions with nitroxides, which are important for the synthesis of various compounds and the study of their properties.
Used in the Synthesis of Cardioprotectants:
3-(AMINOMETHYL)-PROXYL is used as a reactant in the synthesis of adenosine methycarboxamides, which are compounds with potential cardioprotective properties. This contributes to the development of new therapeutic agents for the treatment of cardiovascular diseases.

InChI:InChI=1/C9H19N2O/c1-8(2)5-7(6-10)9(3,4)11(8)12/h7H,5-6,10H2,1-4H3

Upstream product

• 78151-25-4 3-azidomethyl-2,2,5,5-tetramethyl-2,3,4,5-tetrahydropyrrole-1-oxyl 
• 78151-24-3 2,2,5,5-tetramethyl-3-p-toluenesulfonyloxy-2,3,4,5-tetrahydropyrrole-1-oxyl 
• 27298-75-5 3-(hydroxymethyl)-2,2,5,5-tetramethylpyrrolidinyl-1-oxy 
• 45985-26-0 4-oxo-2,2,6,6-tetramethylpiperidin-oxyl 
• 46147-12-0 3-carbamoyl-2,2,5,5-tetramethylpyrrolidin-1-yloxy 
• 78140-46-2 C₂₇H₃₂N₂OP 

Downstream Products

• 1610049-92-7 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-[(1-oxyl-2,2,5,5-tetramethylpyrrolidin-3-ylmethyl)aminomethyl]chroman-4-one 
• 99688-21-8 iron(III) 5-(2-((((2,2,5,5-tetramethyl-1-oxypyrrolidin-3-yl)methylene)amido)carbonyl)phenyl)-10,15,20-tri-p-tolylporphyrin chloride 
• 78140-52-0 2,2,5,5-tetramethyl-3-isothiocyanatomethylpyrrolidine-1-oxyl 

Relevant academic research and scientific papers

Synthesis of Isoselenocyanates

Isoselenocyanates were synthesized by two methods under phase-transfer conditions (50% aq NaOH, CH2Cl2, Aliquat 336); the first started from isocyanides and selenium and gave isoselenocyanates in 61-89% yields, while the second started from amines and used chloroform and selenium, by applying sequentially the Hofmann isonitrile synthesis and the addition of selenium, in 4-70% yields.

Reaction of Nitroxides with Sulfur Containing Compounds II [1]. Preparation of Nitroxides Bearing an Isothiocyanate Substituent in View of the Nitroxyl Group Reduction with Thiophosgene

The reaction of thiophosgene with 2,2,6,6-tetramethylpiperidine-1-oxyl (used as a model nitroxyl radical) was examined. 2,2,6,6-Tetramethylpiperidine and 2,2,6,6-tetramethyl-1-hydroxypiperidine were identified as products. The reaction is not competitive with the reaction of thiophosgene with an amino group. Thus, three nitroxides with an isothiocyanate group were synthesized from thiophosgene and the nitroxides containing the amino substituent.