546084-44-0

Basic information

• Product Name: 1,2-Cyclohexanediamine, N,N'-bis[(4-bromophenyl)methyl]-, (1R,2R)-
• CAS NO: 546084-44-0
• Molecular Formula: C20H24Br2N2
• Molecular Weight: 452.232
• Mol File: 546084-44-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2-Cyclohexanediamine, N,N'-bis[(4-bromophenyl)methyl]-, (1R,2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Cyclohexanediamine, N,N'-bis[(4-bromophenyl)methyl]-, (1R,2R)-(546084-44-0)
• EPA Substance Registry System: 1,2-Cyclohexanediamine, N,N'-bis[(4-bromophenyl)methyl]-, (1R,2R)-(546084-44-0)

Safety Data

• Hazardous Substances Data: 546084-44-0(Hazardous Substances Data)

Upstream product

• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 1122-91-4 4-bromo-benzaldehyde 
• 546084-25-7 (R,R)-1,3-bis[(4-bromophenyl)methyl]-2-chlorooctahydro-2-allyl-1H-1,3,2-benzodiazasilole 
• 32044-22-7 (1R,2R)-1,2-diaminocyclohexane tartrate 
• 500581-16-8 (1R,2R)-N,N'-di(4'-bromobenzylidene)-1,2-diaminocyclohexane 
• 549520-99-2 (1R,2R)-N,N'-bis(5-bromobenzylidene)diiminocyclohexane 

Downstream Products

• 546084-25-7 (R,R)-1,3-bis[(4-bromophenyl)methyl]-2-chlorooctahydro-2-allyl-1H-1,3,2-benzodiazasilole 
• 804559-38-4 (R,R)-crotylsilane 
• 804559-39-5 (R,R)-trans EZ-CrotylMix 
• 869991-61-7 (3aR,7aR)-1,3-bis(4-bromobenzyl)-2-chloro-2-((E)-2-methylbut-2-enyl)octahydro-1H-benzo[d]-1,3,2-diazasilole 
• 1093871-61-4 C₂₂H₂₈Br₂N₂ 

Relevant articles and documents

Total synthesis of the Tiacumicin B (lipiarmycin A3/fidaxomicin) aglycone

Tiacumicin B (lipiarmycin A3, fidaxomicin) is an atypical macrolide antibiotic which is used for the treatment of Clostridium difficile infections. Tiacumicin B is also a potent inhibitor of Mycobacterium tuberculosis, but due to its limited oral bioavailability is unsuitable for systemic therapy. To provide a basis for structure-activity studies that might eventually lead to improved variants of tiacumicin B, we have developed an efficient approach to the synthesis of the tiacumicin B aglycone. The synthesis features a high-yielding intramolecular Suzuki cross-coupling reaction to effect macrocyclic ring closure. Key steps in the synthesis of the macrocyclization precursor were a highly selective, one-pot Corey-Peterson olefination and an ene-diene cross-metathesis reaction. Depending on the reaction conditions, the final deprotection delivered either the fully deprotected tiacumicin B aglycone or partially protected versions thereof.

Total Synthesis of (-)-Disorazole C1

Disorazoles represent a powerful class of highly potent antitubulin natural products isolated from myxobacteria. Herein, we describe a scalable and robust synthesis of (-)-disorazole C1 with high stereoselectivity, featuring quite simple reaction conditio

Chiral hybrid silica: Sol-gel heterogenisation of trans-(1R,2R)- diaminocyclohexane ligands for the rhodium catalysed enantioselective reduction of acetophenone

The synthesis of derivatives of trans-(1R,2R)-diaminocyclohexane with different substituents on the nitrogen atoms has been achieved. Rhodium complexes of these chiral ligands were evaluated as homogeneous catalysts for the asymmetric hydride transfer red