5461-36-9

Basic information

• Product Name: N-benzyldecan-1-amine
• CAS NO: 5461-36-9
• Molecular Formula: C₁₇H₂₉N*ClH
• Molecular Weight: 247.4189
• Mol File: 5461-36-9.mol

Chemical Properties

• Boiling Point: 338.1°C at 760 mmHg
• Flash Point: 135.2°C
• Density: 0.884g/cm³
• Vapor Pressure: 0.000101mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: N-benzyldecan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyldecan-1-amine(5461-36-9)
• EPA Substance Registry System: N-benzyldecan-1-amine(5461-36-9)

Safety Data

• Hazardous Substances Data: 5461-36-9(Hazardous Substances Data)

Upstream product

• 112-31-2 caprinaldehyde 
• 100-47-0 benzonitrile 
• 20172-41-2 N-benzylidenedecan-1-amine 
• 100-52-7 benzaldehyde 
• 2016-57-1 1-aminodecane 

Downstream Products

• 1558953-49-3 1-(N-(N^α,N^ε-di-Boc-Lys)-N-decylamino)methylbenzene 

Relevant articles and documents

General Synthesis of Secondary Alkylamines by Reductive Alkylation of Nitriles by Aldehydes and Ketones

The development of C?N bond formation reactions is highly desirable due to their importance in biology and chemistry. Recent progress in 3d metal catalysis is indicative of unique selectivity patterns that may permit solving challenges of chemical synthesis. We report here on a catalytic C?N bond formation reaction—the reductive alkylation of nitriles. Aldehydes or ketones and nitriles, all abundantly available and low-cost starting materials, undergo a reductive coupling to form secondary alkylamines and inexpensive hydrogen is used as the reducing agent. The reaction has a very broad scope and many functional groups, including hydrogenation-sensitive examples, are tolerated. We developed a novel cobalt catalyst, which is nanostructured, reusable, and easy to handle. The key seems the earth-abundant metal in combination with a porous support material, N-doped SiC, synthesized from acrylonitrile and a commercially available polycarbosilane.

ANTIMICROBIAL COMPOUNDS, THEIR SYNTHESIS AND APPLICATIONS THEREOF

The present disclosure relates to the field of medicinal chemistry and more particularly to the development of antimicrobial compounds. The disclosure relates to the synthesis and characterization of compounds comprising aromatic radical or an aliphatic radical, an alkyl amine and amino acid moiety wherein said compounds exhibit antimicrobial activity against various drug-sensitive and drug-resistant pathogenic 10 microorganisms.

Small molecular antibacterial peptoid mimics: The simpler the better!

The emergence of multidrug resistant bacteria compounded by the depleting arsenal of antibiotics has accelerated efforts toward development of antibiotics with novel mechanisms of action. In this report, we present a series of small molecular antibacterial peptoid mimics which exhibit high in vitro potency against a variety of Gram-positive and Gram-negative bacteria, including drug-resistant species such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. The highlight of these compounds is their superior activity against the major nosocomial pathogen Pseudomonas aeruginosa. Nontoxic toward mammalian cells, these rapidly bactericidal compounds primarily act by permeabilization and depolarization of bacterial membrane. Synthetically simple and selectively antibacterial, these compounds can be developed into a newer class of therapeutic agents against multidrug resistant bacterial species.