546144-89-2Relevant academic research and scientific papers
Synthesis of biologically active thiazolo-benzopyranyl-s-triazine derivatives
Mulwad,Shirodkar, Jyoti M.
, p. 621 - 626 (2007/10/03)
6-Amino-2-oxo-2H [1]-benzopyran on oxidative cyclisation with potassium thiaocynate, acetic acid and bromine at 0-5°C gives 2-amino-7H [6]- thiazolo [5,4-d] benzopyran-7-one 1, which on treatment with cyanuric chloride in alcohol gives 2-(2′-amino-7′-oxo-7′H [6′]- thiazolo [5′, 4′-d] benzopyranyl)-4-6-dichloro-s-triazine 2. 6-Amino-2-oxo-2H [1]-benzopyran on refluxing with ammonium thiocynate in hydrochloric acid and ethanol gives 6-thioureido-2H [1]-benzopyran-2-one 3. Compound 2 on refluxing with 3 in alcohol gives 2-(2′-amino-7′-oxo-7′H [6′]- thiazolo [5′, 4′-d] benzopyranyl)-4-(6″-thioureido-2″H-[1″]-2 ″-oxo-benzopyranyl)-6-chloro-s-triazine 4. The similar reaction is repeated on 4 to give 2- (2′-amino-7′-oxo-7′H [6′]- thiazolo [5′, 4′-d] benzopyranyl)-4-(6″-thioureido-2″H [1″]-2″-oxo benzopyranyl)-6-(6?-thioureido-2?H-[1?]-2 ?-oxo-benzopyranyl)-s-triazine 5. The structures of all compounds are confirmed on the basis of analytical and spectral data. Some of the compounds show significant antibacterial activity.
