546145-03-3

Basic information

• Product Name: N-(2-AMinoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetaMide
• Synonyms: N-(2-AMinoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetaMide
• CAS NO: 546145-03-3
• Molecular Formula: C9H14N4O3
• Molecular Weight: 226.23246
• Mol File: 546145-03-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: N-(2-AMinoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMinoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetaMide(546145-03-3)
• EPA Substance Registry System: N-(2-AMinoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetaMide(546145-03-3)

Safety Data

• Hazardous Substances Data: 546145-03-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-Aminoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide is utilized as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to serve as a building block in the creation of new medicinal compounds, potentially leading to the development of innovative treatments for a range of diseases and conditions.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-(2-Aminoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide is used for the exploration of its potential biological activity. The presence of the aminoethyl and dioxo-dihydropyrimidinylacetamide groups indicates that N-(2-AMinoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetaMide may interact with biological targets, making it a subject of interest for the design and synthesis of new therapeutic agents.
While the specific applications and reasons for the use of N-(2-AMinoethyl)-2-(5-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)acetaMide in different industries are not explicitly detailed in the provided materials, the general applications in the pharmaceutical industry and medicinal chemistry research are inferred based on the compound's characteristics and potential. Further research and development would be necessary to fully understand and exploit the compound's capabilities in various applications.

Upstream product

• 107-15-3 ethylenediamine 
• 157401-17-7 2-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetonitrile 
• 65-71-4 thymin 
• 20924-05-4 thymidyl acetic acid 
• 134456-94-3 methyl (5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)ethanoate 

Relevant articles and documents

Syntheses of N-substituted thymine thioacetamides. A novel approach to site selective acylation of diaminoalkanes

A new series of N-substituted thiocarbamoyl derivatives containing histamine, tryptamine, and other moieties having at least one amino group attached to an aliphatic chain, has been synthesized from (1-thyminyl)thioacetamide in good isolated yields (69-86%). N-[2-(4-Imidazolyl)ethyl](1-thyminyl)thioacetamide was hydrolyzed to its amide on prolonged heating in water. Ammonium sulfide (20-22% solution in water) has found interesting new applications in the efficient synthesis of N-[2-(3-indolyl)ethyl](1-thyminyl)thioacetamide and site selective acylation of diaminoalkanes, starting directly from nitriles. (C) 2000 Elsevier Science Ltd.

Melamine driven supramolecular self-assembly of nucleobase derivatives in water

Water-soluble supramolecular polymers, especially made up of biomolecules, are ideally suited to build new biomaterials that can mimic or interact with dynamic, biological environments. Here, two derivatives from thymine (T), that is N-[2-(3,4-Dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidinyl)acetyl]-L-phenylalanine (T-phe) and N-(2-Aminoethyl)-3,4-dihydro-5-methyl-2,4-dioxo-1(2H)-pyrimidineacetamide (T-NH2) were synthesized. Then the optimal condition for self-assembly of T-phe and T-NH2 driven by melamine (M) was explored. It was observed that M/T kept at 1:3 with equivalent T-phe and T-NH2 under neutral environment resulted in long fibers (>1 μm) with extremely high aspect ratios, which suggested that electrostatic and π-stacking interactions could be effectively orchestrated by hydrogen bonds to direct the hierarchical assembly. Furthermore, hydrogels were spontaneously generated with a concentrated solution of T-phe, T-NH2, and M due to the fibril entanglement. Given its biomimetic nature and efficient self-assembly process, this newly developed supramolecular polymer stacked by tetrameric structures represented an innovative concept and pathway for novel bio-inspired materials.

Thymine-based near-infrared squaraine dye probe and preparation method and application thereof

The invention relates to the field of dye probe preparation, particularly to a thymine-based near-infrared squaraine dye probe and a preparation method and application thereof. The preparation method comprises taking 1-(3-dimethyl aminopropyl)-3-ethyl carbodiimide and 1-hydroxybenzothioamide as catalysts, N, N-diisopropylethylamine as organic base and dimethyl formamide as solvent to perform key reaction for producing amido bonds, and taking ethylenediamine as truss arm to link thymine and unsymmetric squaraine dyes via covalent bonds to prepare the unsymmetric thymine-based near-infrared squaraine dye probe. Existing near-infrared dye probes mainly focus on recognition of ions of Fe3+, and the thymine-based near-infrared squaraine dye probe solves the problem of selective recognition of Fe2+ and Co2+ in near-infrared absorbing areas.

Ratiometric fluorescent chemosensor for Hg2+ based on heptamethine cyanine containing a thymine moiety

Based on a T-Hg2+-T binding mode, a sensitive ratiometric fluorescent chemosensor for aqueous Hg2+ was developed with a heptamethine cyanine chromophore containing a thymine moiety.