5463-91-2Relevant academic research and scientific papers
Pro-apoptotic activity of lipidic α-amino acids isolated from Protopalythoa variabilis
Wilke, Diego Veras,Jimenez, Paula Christine,Araújo, Renata Mendona,Da Silva, Wildson Max Barbosa,Pessoa, Otília Deusdênia Loiola,Silveira, Edilberto Rocha,Pessoa, Claudia,De Moraes, Manoel Odorico,Skwarczynski, Mariusz,Simerska, Pavla,Toth, Istvan,Costa-Lotufo, Letícia Veras
scheme or table, p. 7997 - 8004 (2011/02/23)
Lipidic α-amino acids (LAAs) have been described as non-natural amino acids with long saturated or unsaturated aliphatic chains. In the continuing prospect to discover anticancer agents from marine sources, we have obtained a mixture of two cytotoxic LAAs (1a and 1b) from the zoanthid Protopalythoa variabilis. The anti-proliferative potential of 14 synthetic LAAs and 1a/1b were evaluated on four tumor cell lines (HCT-8, SF-295, MDA-MB-435, and HL-60). Five of the synthetic LAAs showed high percentage of tumor cell inhibition, while 1a/1b completely inhibited tumor cell growth. Additionally, apoptotic effects of 1a/1b were studied on HL-60 cell line. 1a/1b-treated cells showed apoptosis morphology, loss of mitochondrial potential, and DNA fragmentation.
Microwave-assisted synthesis of unnatural amino acids
Young, Douglas D.,Torres-Kolbus, Jessica,Deiters, Alexander
experimental part, p. 5478 - 5480 (2009/05/30)
Microwave irradiation has been proven to be a useful tool in the rapid assembly of racemic unnatural amino acids in only two steps. Additional benefits of this methodology are the commercial availability of the inexpensive starting materials and the high yields and high purities of the final amino acid products.
