644-90-6Relevant articles and documents
Hexyl-modified morpholine-2,5-dione-based oligodepsipeptides with relatively low glass transition temperature
Peng, Xingzhou,Behl, Marc,Zhang, Pengfei,Mazurek-Budzyńska, Magdalena,Razzaq, Muhammad Yasar,Lendlein, Andreas
, p. 318 - 326 (2016/11/18)
Oligodepsipeptides (oDPs), alternating copolymers of an α-amino acid and an α-hydroxy acid, are typically created by ring-opening polymerization (ROP) of morpholine-2,5-dione derivatives (MDs). In general, oDPs exhibit relatively high glass transition temperatures (Tgs) caused by the strong intermolecular H-bonding between amide and ester bonds. So far, it was not reported that variation at α-amino acid moieties in MDs monomers lead to lower Tg. Here we explored whether the thermal properties of the oDPs can be adjusted by introducing a hexyl side chain in the α-hydroxy acid part of the MDs. By synthesizing a MD with an atactic pendant hexyl group at position 3, the influence of a modification at position 6 compared to a modification at position 3 towards ROP was investigated. In both cases the atactic bulky side groups hindered the H-bonding between chain segments resulting in a significant reduction of the Tgs to a temperature around human body temperature (32 and 36 °C) in contrast to ROP of a MD providing a methyl group at position 3 and a Tg ≈ 65 °C. Such oDPs could be interesting candidate materials for biomedical applications such as degradable implants.
Biocatalytic asymmetric synthesis of unnatural amino acids through the cascade transfer of amino groups from primary amines onto keto acids
Park, Eul-Soo,Dong, Joo-Young,Shin, Jong-Shik
, p. 3538 - 3542 (2014/01/06)
Flee to the hills: An unfavorable equilibrium in the amino group transfer between amino acids and keto acids catalyzed by α-transaminases was successfully overcome by coupling with a ω-transaminase reaction as an equilibrium shifter, leading to efficient asymmetric synthesis of diverse unnatural amino acids, including L-tert-leucine and D-phenylglycine. Copyright
Synthesis of a library of polycationic lipid core dendrimers and their evaluation in the delivery of an oligonucleotide with hVEGF inhibition
Parekh, Harendra S.,Marano, Robert J.,Rakoczy, Elizabeth P.,Blanchfield, Joanne,Toth, Istvan
, p. 4775 - 4780 (2007/10/03)
This article follows on from our previous work in the area of non-viral gene delivery using polycationic dendrimers (PCDs). Herein we report on the synthesis and efficacy of a new library of lipid core PCDs in the delivery of the anti-angiogenic oligonucleotide (ODN-1) to retinal pigment epithelial cells. ELISA was used to monitor hVEGF levels in cells transfected with dendriplexes, Cytofectin GSV and control (non-transfected). At 48 h, hVEGF titres had returned to that of the untransfected control for Cytofectin GSV however, a number of dendriplexes continued to exhibit a marked reduction in hVEGF titres.
