54632-11-0

Basic information

• Product Name: 3-AMINO-5-CHLOROPYRAZINE-2-CARBONITRILE
• Synonyms: 3-AMINO-5-CHLOROPYRAZINE-2-CARBONITRILE;3-Amino-5-chloro-2-cyanopyrazine;3-Amino-5-chloro-2-cyanopyrazine, 3-Amino-5-chloro-2-cyano-1,4-diazine
• CAS NO: 54632-11-0
• Molecular Formula: C₅H₃ClN₄
• Molecular Weight: 154.56
• Mol File: 54632-11-0.mol

Chemical Properties

• Melting Point: 194-196 ºC
• Boiling Point: 368.053°C at 760 mmHg
• Flash Point: 176.393°C
• Appearance: /
• Density: 1.53
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: 2-8°C
• PKA: -0.87±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-5-CHLOROPYRAZINE-2-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-CHLOROPYRAZINE-2-CARBONITRILE(54632-11-0)
• EPA Substance Registry System: 3-AMINO-5-CHLOROPYRAZINE-2-CARBONITRILE(54632-11-0)

Safety Data

• Hazardous Substances Data: 54632-11-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Amino-5-chloropyrazine-2-carbonitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 3-Amino-5-chloropyrazine-2-carbonitrile serves as a building block for the synthesis of various agrochemicals, including pesticides and herbicides. Its reactivity and versatility enable the creation of effective compounds for agricultural use.
Used in the Development of Novel Materials:
3-Amino-5-chloropyrazine-2-carbonitrile is utilized in the development of novel materials due to its unique chemical properties. Its potential applications in this field include the creation of new polymers, dyes, and other advanced materials with specific properties.
Used in Organic Chemistry as a Versatile Intermediate:
3-Amino-5-chloropyrazine-2-carbonitrile is commonly used as a versatile intermediate in organic chemistry. Its reactivity and the presence of various functional groups make it suitable for the synthesis of a wide range of organic compounds, contributing to the advancement of chemical research and the development of new chemical entities.

InChI:InChI=1/C5H3ClN4/c6-4-2-9-3(1-7)5(8)10-4/h2H,(H2,8,10)

Upstream product

• 42770-07-0 2-amino-3-cyanopyrazine-1-oxide 

Downstream Products

• 135291-84-8 3-amino-5-methoxypyrazine-2-carbonitrile 
• 440124-25-4 3-bromo-5-chloro-pyrazine-2-carbonitrile 
• 1065267-82-4 (S)-5-(5-cyclopropyl-1H-pyrazol-3-ylamino)3-(1-(5-fluoropyridin-2-yl)ethylamino)pyrazine-2-carbonitrile 
• 1065267-77-7 3-{[(1R)-1-(3,5-difluoropyridin-2-yl)ethyl]amino}-5-[(5-methyl-1H-pyrazol-3-yl)amino]pyrazine-2-carbonitrile 
• 1065267-57-3 3-([(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]amino)-5-[(5-methyl-1H-pyrazol-3-yl)amino]pyrazine-2-carbonitrile 
• 1065267-72-2 3-(1-(5-fluoropyridin-2-yl)ethylamino)-5-(5-methyl-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile 
• 1065267-36-8 3-bromo-5-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile 
• 1065266-91-2 3-bromo-5-[(5-methyl-1H-pyrazol-3-yl)amino]pyrazine-2-carbonitrile 

Relevant articles and documents

Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors

The design, synthesis and biological evaluation of a series of pyrazol-3-ylamino pyrazines as potent and selective JAK2 kinase inhibitors is reported, along with the pharmacokinetic and pharmacodynamic properties of lead compounds.

PYRAZOLYL-AMINO-SUBSTITUTED PYRAZINES AND THEIR USE FOR THE TREATMENT OF CANCER

The present invention relates to compounds of Formula (I): and to their pharmaceutical compositions, and to their methods of use. These novel compounds provide a treatment for myeloproliferative disorders and cancer.