54635-62-0

Usage

Biological Activity

Potent 5-HT 6 receptor agonist (EC 50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC 50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT 6 , 5-HT 1D , 5-HT 1B , 5-HT 2A , 5-HT 2C , 5-HT 4 , 5-HT 1A and 5-HT 7 receptors respectively). Shows moderate affinity at 5-HT 3 receptors (IC 50 = 34 nM).

InChI:InChI=1/C14H15ClN2.ClH/c1-9-14(10-4-6-16-7-5-10)12-8-11(15)2-3-13(12)17-9;/h2-4,8,16-17H,5-7H2,1H3;1H

Upstream product

• 41661-47-6 piperidin-4-one 
• 1075-35-0 5-chloro-2-methylindole 
• 40862-32-6 1-iodo-3-(p-fluorophenylcarbonyl)propane 
• 400801-74-3 4-(5'-chloro-2'-methyl-3'-indolyl)-piperidine 
• 40064-34-4 4-piperidone monohydrochloride monohydrate 

Downstream Products

• 1442104-24-6 1-(benzenesulfonyl)-5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)indole 
• 1365043-69-1 N-{4-[4-(5-chloro-2-methyl-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]butyl}-3-methylbenzene-1-sulfonamide 
• 1365044-05-8 N-{3-[4-(5-chloro-2-methyl-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]propyl}-3-methylbenzene-1-sulfonamide 
• 1365044-27-4 N-{2-[4-(5-chloro-2-methyl-1H-indol-3-yl)-1,2,3,6-tetrahydropyridin-1-yl]ethyl}-3-methylbenzene-1-sulfonamide 

Relevant academic research and scientific papers

Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6- tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT6 receptor agonists

To further investigate the structure-activity relationship (SAR) of the 5-hydroxytryptamine type 6 (5-HT6) receptor agonist 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (EMD386088, 6), a series of 2-methyl-3-(1,2,3,6-tetrahydr

2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT 6 receptor agonists

A series of 2-alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles were synthesized and evaluated for their 5-HT6 activity. The most potent agonist in this series was 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)- 1H-indole with an ICsub

(Indolyl-piperidino or -1,2,5,6-tetrahydro-pyridyl)-p-fluoro-butyrophenones and salts thereof

Compounds of the formula SPC1 Wherein R1 is hydrogen, chlorine, methyl, methoxy or trifluoromethyl, R2 is hydrogen or methyl, R3 is methyl or phenyl, and R4 and R5 together form a double bond or, in case R1 is chloro, methyl or trifluoromethyl, are also hydrogen atoms, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as sedatives and tranquilizers.