5464-44-8

Usage

Uses

Used in Pharmaceutical Synthesis:
N-PHTHALOYL-DL-METHIONINE is used as a reactant for the synthesis of various pharmaceuticals and organic compounds, leveraging its unique chemical properties to contribute to the development of new medications.
Used in Medical Treatments:
In the medical field, N-PHTHALOYL-DL-METHIONINE is used as a potential treatment for specific conditions such as kidney disease and certain types of cancer, capitalizing on its therapeutic effects that are still under investigation.
Used in Industrial Processes:
N-PHTHALOYL-DL-METHIONINE is utilized as a chelating agent for heavy metal ions in industrial applications, playing a crucial role in environmental remediation and other processes where metal ion management is necessary.
Used in Environmental Remediation:
In environmental applications, N-PHTHALOYL-DL-METHIONINE is used as a remediation agent to chelate and remove heavy metals from contaminated sites, contributing to the cleanup and safety of ecosystems and human habitats.

Upstream product

• 85-44-9 phthalic anhydride 
• 59-51-8 DL-methionine 

Downstream Products

• 39739-05-4 methyl-(S)-2-phthalimido-4-methylthiobutanoate 
• 55985-04-1 methyl (S)-4-methylsulfanyl-2-phthalimidobutanoate 
• 109541-75-5 methyl 1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)cyclopropanecarboxylate 
• 120831-43-8 N,N-phthaloyl-methionine-(N-diphenylacetyl-p-toluidide) 

Relevant academic research and scientific papers

Palladium-Catalyzed Decarbonylation of Amino Acid Derivatives via C-C Bond and C-N Bond Dual Activations

A unique decarbonylation of an amino acid derivative catalytic system has been established via palladium-catalyzed C-C bond and C-N bond dual activations. By employing 8-aminoquinoline as the directing group, this transformation has been found to facilitate the high chemoselectivity to decarbonylation of amino acid derivatives rather than intramolecular deamination or cross-dehydrogenative coupling reactions. This method provides a straightforward avenue for constructing diverse functionalized amide compounds in good to excellent yields. We proposed a possible reaction pathway that may go through the C-C bond and C-N bond dual activations on the basis of the mechanistic studies.

Synthesis of the First Representatives of Spiro-1λ6-isothiazolidine-1,1,4-triones

A strategy for the construction of spiro[cycloalkane-1,3′-1′λ6-isothiazolidine]-1′,1′,4′-triones through the sulfonylation of 1-aminocyclopropane- and 1-aminocyclobutanecarboxylates with methanesulfonyl chloride followed by alkylation with methyl iodide and subsequent cyclization in the presence of potassium tert-butoxide in N,N-dimethylformamide is reported. An efficient synthesis of starting 1-aminocyclopropane- and 1-aminocyclobutanecarboxylic acids was developed. The reaction of spiro[cycloalkane-1,3′-1′λ6-isothiazolidine]-1′,1′,4′-triones with N,N-dimethylformamide dimethyl acetal (DMF-DMA) gives 5′-[(Z)-(dimethylamino)methylene]spiro[cycloalkane-1,3′-1′λ6-isothiazolidine]-1′,1′,4′-triones, the structure of which was confirmed by X-ray diffraction study.