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102392-05-2

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102392-05-2 Usage

General Description

The chemical compound "1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]-" is a derivative of isoindole-1,3(2H)-dione that contains a piperazine group and a 2-methoxyphenyl group. It is commonly used as a pharmaceutical ingredient due to its potential medical applications. 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(2-Methoxyphenyl)-1-piperazinyl]butyl]- has been studied for its potential use in the treatment of various medical conditions, including mental health disorders and neurological disorders. Additionally, it may also have applications in the development of new drugs for other therapeutic areas. Its complex structure and versatile properties make it a valuable target for further research and development in the pharmaceutical industry.

Check Digit Verification of cas no

The CAS Registry Mumber 102392-05-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,2,3,9 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 102392-05:
(8*1)+(7*0)+(6*2)+(5*3)+(4*9)+(3*2)+(2*0)+(1*5)=82
82 % 10 = 2
So 102392-05-2 is a valid CAS Registry Number.

102392-05-2Relevant articles and documents

Synthesis, preclinical evaluation and molecular modelling of macrocyclic appended 1-(2-methoxyphenyl)piperazine for 5-HT1A neuroreceptor imaging

Hazari, Puja Panwar,Prakash, Surbhi,Meena, Virendra Kumar,Singh, Niraj,Chuttani, Krishna,Chadha, Nidhi,Singh, Pooja,Kukreti, Shrikant,Mishra, Anil Kumar

, p. 7288 - 7301 (2016)

5-HT1A receptors are known to be implicit in a number of neuropsychiatric fluctuations related to mood and anxiety. Their visualization in the human brain using PET, SPECT or MRI is of great importance in the management and treatment of neurolo

Synthesis and radiolabelling of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl) butyl)-benzamide, a potential dopamine D3 antagonist for SPECT studies

Staelens,Dumont,De Vos,Oltenfreiter,Vandecapelle,Dierckx,Slegers

, p. 297 - 305 (2003)

Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neur

Photochromic Dopamine Receptor Ligands Based on Dithienylethenes and Fulgides

Lachmann, Daniel,Studte, Carolin,M?nnel, Barbara,Hübner, Harald,Gmeiner, Peter,K?nig, Burkhard

, p. 13423 - 1343 (2017)

We describe the incorporation of the well-investigated class of photochromic dithienylethenes (DTEs) and fulgides into known dopamine receptor ligands such as 1,4-disubstituted aromatic and hydroxybenzoxazinone piperazines as well as aminoindanes. Subtype

Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands

Elek, Milica,Djokovic, Nemanja,Frank, Annika,Oljacic, Slavica,Zivkovic, Aleksandra,Nikolic, Katarina,Stark, Holger

, (2021/02/26)

Dopamine is an important neurotransmitter in the human brain and its altered concentrations can lead to various neurological diseases. We studied the binding of novel compounds at the dopamine D2 (D2R) and D3 (D3/sub

Design, synthesis, and evaluation of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamides as selective dopamine D3 receptor ligands

Chen, Peng-Jen,Taylor, Michelle,Griffin, Suzy A.,Amani, Armaghan,Hayatshahi, Hamed,Korzekwa, Kenneth,Ye, Min,Mach, Robert H.,Liu, Jin,Luedtke, Robert R.,Gordon, John C.,Blass, Benjamin E.

supporting information, p. 2690 - 2694 (2019/08/07)

As part of our on-going effort to explore the role of dopamine receptors in drug addiction and identify potential novel therapies for this condition, we have a identified a series of N-(4-(4-phenyl piperazin-1-yl)butyl)-4-(thiophen-3-yl)benzamide D3 ligands. Members of this class are highly selective for D3 versus D2, and we have identified two compounds (13g and 13r) whose rat in vivo IV pharmacokinetic properties that indicate that they are suitable for assessment in in vivo efficacy models of substance use disorders.

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