5465-34-9

Usage

Uses

Used in Oncology:
NSC28975 is used as an anticancer agent for its ability to inhibit the growth of various cancer cell lines, including breast, prostate, and lung cancer. It functions by disrupting the microtubule network within cells, which ultimately leads to cell death.
Used in Neurodegenerative Disease Research:
NSC28975 is used as a potential treatment for neurodegenerative diseases due to its ability to inhibit microtubule function, making it a candidate for further research and development in this area.

InChI:InChI=1/C8H8N2O4/c1-4-2-5(8(11)12)7(9)6(3-4)10(13)14/h2-3H,9H2,1H3,(H,11,12)

Upstream product

• 573692-68-9 5-methyl-3-nitro-2-(2,2,2-trifluoroacetyl)aminobenzoic acid 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 648934-53-6 2-[bis-(2,2,2-trifluoroacetyl)amino]-5-methylbenzoic acid 
• 90418-79-4 5-methyl-7-nitroindoline-2,3-dione 

Downstream Products

• 37901-87-4 2,3-diamino-5-methylbenzoic acid 
• 1248541-72-1 methyl 2-amino-5-methyl-3-nitrobenzoate 
• 1332996-52-7 2-amino-5-methyl-3-nitrobenzamide 
• 1332996-54-9 2,3-diamino-5-methylbenzamide 
• 854645-22-0 2-iodo-5-methyl-3-nitro-benzoic acid methyl ester 
• 124340-70-1 6-Methyl-2-phenyl-1H-benzoimidazole-4-carboxylic acid (2-dimethylamino-ethyl)-amide 
• 124340-98-3 2-phenyl-6-methyl-1H-benzimidazole-4-carboxylic acid 
• 90414-60-1 2-iodo-5-methyl-3-nitrobenzoic acid 
• 113882-33-0 5-Methyl-3-nitrobenzoic acid 

Relevant academic research and scientific papers

OXADIAZOLE DERIVATIVES AND PHARMACEUTICAL USES THEREOF

PROBLEM TO BE SOLVED: To provide therapeutic or preventive agents for various diseases or symptoms associated with a serotonin 4 receptor (particularly, neuropsychiatric diseases such as Alzheimer-type dementia). SOLUTION: The present invention provides a compound represented by formula (1) or a pharmaceutically acceptable salt thereof. In the formula (1), Het represents formula (Het-1) or the like, A represents formula (A-1) or the like, B represents (B-1) or the like, R1A represents a hydrogen atom, an alkyl group or the like, R2A, R5, R6 and R7 represent a hydrogen atom, a halogen atom, an alkyl group or the like, R8 and R9 represent a hydrogen atom, an alkyl group or the like, and l represents an integer of 0-4. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

DIHYDROOROTATE DEHYDROGENASE INHIBITORS

The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists

A series of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones (QXs) related to licostinel (Acea 1021) was synthesized and evaluated as antagonists for the glycine site of the N-methyl-D-asparate (NMDA) receptor. The in vitro potency of these