5467-89-0Relevant academic research and scientific papers
An efficient synthesis of pyrido[1,2-a]indoles through aza-Nazarov type cyclization
Karthikeyan, Iyyanar,Arunprasath, Dhanarajan,Sekar, Govindasamy
supporting information, p. 1701 - 1704 (2015/03/03)
Transition metal free Br?nsted acid mediated synthesis of biologically important pyrido[1,2-a]indole scaffolds through aza-Nazarov type cyclization of readily available diaryl(2-pyridyl)methanol using formic acid has been developed. This methodology has b
Iron-catalyzed C-H bond functionalization for the exclusive synthesis of pyrido[1,2-a]indoles or triarylmethanols
Karthikeyan, Iyyanar,Sekar, Govindasamy
supporting information, p. 8055 - 8063 (2015/01/09)
The efficient and selective iron-catalyzed C-H activation of 2-benzhydrylpyridine derivatives was employed for the preparation of pyrido[1,2-a]indoles through an intramolecular C-H amination reaction. In the presence of molecular oxygen as the sole oxidant, the same 2-benzhydrylpyridines were also used for the synthesis of the corresponding tertiary alcohols. In these approaches, the iron catalyst was used to selectively activate the C(sp2)-H bond of 2-benzhydrylpyridine, in the case of the intramolecular ring-closing C-H amination reaction in which the pyridine nitrogen atom was a directing group as well as a nucleophile, and the C(sp3)-H bond of the same compound, in the case of the oxidation reaction to give the corresponding triaryl carbinol.
