5467-92-5

Basic information

• Product Name: isoquinolin-1-yl(diphenyl)methanol
• CAS NO: 5467-92-5
• Molecular Formula: C₂₂H₁₇NO
• Molecular Weight: 311.3765
• Mol File: 5467-92-5.mol

Chemical Properties

• Boiling Point: 510.3°C at 760 mmHg
• Flash Point: 262.4°C
• Density: 1.208g/cm³
• Vapor Pressure: 3.09E-11mmHg at 25°C
• Refractive Index: 1.676
• CAS DataBase Reference: isoquinolin-1-yl(diphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: isoquinolin-1-yl(diphenyl)methanol(5467-92-5)
• EPA Substance Registry System: isoquinolin-1-yl(diphenyl)methanol(5467-92-5)

Safety Data

• Hazardous Substances Data: 5467-92-5(Hazardous Substances Data)

Upstream product

• 1532-71-4 1-bromoisoquinoline 
• 19658-77-6 1-iodoisoquiniline 
• 464-72-2 tetraphenylethane-1,2-diol 
• 844-25-7 2-benzoyl-1-cyano-1,2-dihydroisoquinoline 
• 591-51-5 phenyllithium 
• 16824-02-5 3-ethoxy-3H-isobenzofuran-1-one 
• 6940-49-4 3-Bromophthalide 
• 16576-23-1 1-benzoylisoquinoline 
• 555-54-4 diphenylmagnesium 
• 65751-84-0 [1]isoquinolyl lithium 
• 119-61-9 benzophenone 

Relevant articles and documents

Green synthesis method of polyaryl substituted methanol

The invention relates to a green synthesis method of polyaryl substituted methanol, in particular to a method for efficiently synthesizing polyaryl substituted methanol in a polar aprotic solvent under the condition of an oxidizing agent by taking polyaryl substituted methane as a raw material and alkali as an additive. The method provided by the invention is green and environment-friendly, avoids using expensive metal catalysts, and has the advantages of low cost, few reaction steps, short time, high yield and the like.

Transition-Metal Free Chemoselective Hydroxylation and Hydroxylation-Deuteration of Heterobenzylic Methylenes

We developed an approach for direct selective hydroxylation of heterobenzylic methylenes to secondary alcohols avoiding overoxidation to ketones by using a KOBu-t/DMSO/air system. Most reactions could reach completion in several minutes to give hydroxylated products in 41-76% yields. Using DMSO-d6, this protocol resulted in difunctionalization of heterobenzylic methylenes to afford α-deuterated secondary alcohols (>93% incorporation). By employing this method, active pharmaceutical ingredients carbinoxamine and doxylamine were synthesized in two steps in moderate yields.

Sodium-Ketyl Radical Anions by Reverse Pinacol Reaction and Their Coupling with Iodoarenes

Transition-metal-free C-C bond formation between aryl iodides and pinacols is presented. Pinacols are readily transformed by deprotonation with NaH to their Na-pinacolates. C-C-bond homolysis at room temperature generates in situ the corresponding Na-ketyl radical anions which react with various aryl iodides in a homolytic aromatic substitution reaction to form tertiary Na-alcoholates. Protonation eventually provides tertiary alcohols in an unprecedented route.