5468-36-0

Usage

Uses

Used in Pharmaceutical Industry:
5,6,7,8-tetrahydro-2H-cinnolin-3-one is used as an intermediate in the synthesis of various biologically active molecules for its potential pharmaceutical applications. Its unique molecular structure and reactivity contribute to the development of new drugs with therapeutic benefits.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 5,6,7,8-tetrahydro-2H-cinnolin-3-one is utilized for its potential as an anticonvulsant and anti-inflammatory agent. Its investigation in these areas may lead to the discovery of novel treatments for epilepsy and inflammatory conditions.
Used in Organic Chemistry Research:
5,6,7,8-tetrahydro-2H-cinnolin-3-one is also used in organic chemistry research to explore its reactivity and potential applications in the synthesis of complex organic molecules, which could have implications in various chemical processes and industries.
Used in Materials Science:
Further research on the properties of 5,6,7,8-tetrahydro-2H-cinnolin-3-one may lead to its development in materials science, where its unique structure could be leveraged to create new materials with specific properties for various applications.

InChI:InChI=1/C8H10N2O/c11-8-5-6-3-1-2-4-7(6)9-10-8/h5H,1-4H2,(H,10,11)

Upstream product

• 41246-23-5 2-Morpholino-2-(2-oxo-cyclohexyl)-acetic acid morpholinium salt 
• 98558-76-0 hydroxy-(2-oxo-cyclohexyl)-acetic acid 
• 108-94-1 cyclohexanone 
• 24731-17-7 ethyl 2-(2-oxocyclohexyl)acetate 
• 4039-30-9 4,4a-Dihydro-cyclohexyl<1,2-c>-3(2H)pyridazinone 

Downstream Products

• 6939-98-6 3-Methoxy-5,6,7,8-tetrahydro-cinnolin 
• 37721-14-5 5,6,7,8-Tetrahydro-cinnolin 
• 32078-92-5 3-Chlorocyclohexyl<1,2-c>pyridazine 

Relevant academic research and scientific papers

Simple synthesis of ring-fused pyridazin-3-ones

Bicyclic and tricyclic pyridazin-3-ones, 6,7-dihydro-5H-cyclopenta[e]-2H-pyridazin-3-one (5), 5,6,7,8-tetrahydrobenzo[e]-2H-pyridazin-3-one (6), 9,10-dihydronaphtho[1,2-e]-2H-pyridazin-3-one (15) and 9,10-dihydronaphtho[1,2-e]-2-methylpyridazin-3-one (21) were prepared in a one-pot procedure by reacting, hydrazine hydrate with a corresponding ketocarboxylic acid.

Preparation of cycloalkano[c]pyridazinones and cycloalkane-condensed pyrrolo[1,2-a]imidazolone, -pyrimidinone and -[1,3]diazepinone stereoisomers

From the 2-ethoxycarbonylmethyl-1-cycloalkanones (1a-c) with hydrazine, the cyclopenta- (2a), cyclohexa- (2b) and cyclohepta[c]pyridazinones (2c) were prepared. 2a-c were transformed to the corresponding dehydro derivatives (3a-c) by means of a recently-developed smooth oxidation method with CuCl2 in acetonitrile. Compounds (1) reacted with α,ω-alkylenediamines to furnish saturated cycloalkano[6]pyrrolo[1,2-cr]diazinones (4a-f). The structures of 4a-f were determined by 1H- and 13C-NMR methods, including DNOE, DEPT and 2D-HSC measurements, and for 4a also by X-ray analysis. The rings of the 2-perhydroindolone and its homologues are cis-fused, while the NH group of the heterocycle containing two N atoms and the annelational hydrogen are cis in all compounds prepared.

Pyridazine derivatives, VII. Synthesis and hypotensive activity of 3-hydrazinocycloalkyl[1,2-c]pyridazines and their derivatives.

The preparation of a series of 3-hydrazinocycloalkyl[1,2-c]pyridazines 7 and some derivatives as hydrazones 8, 9, triazoles 10 and pyrroles 11 are described together with their hypotensive activity in normotensive rats.