98558-76-0

Upstream product

• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 298-12-4 Glyoxilic acid 
• 108-94-1 cyclohexanone 
• 5396-14-5 ethyl 2-oxo-2-(2-oxocyclohexyl)acetate 

Downstream Products

• 107037-39-8 methyl (αR,1S)-α-hydroxy-2-oxocyclohexaneacetate 
• 352547-75-2 C₉H₁₄O₄ 
• 771-12-0 α,2-Dioxocyclohexaneacetic Acid 
• 5468-36-0 Cyclohexyl<1,2-c>-3(2H)pyridazinone 

Relevant academic research and scientific papers

Aqueous organocatalyzed aldol reaction of glyoxylic acid for the enantioselective synthesis of α-hydroxy-γ-keto acids

N-Tosyl-(Sa)-binam-l-prolinamide is an efficient catalyst for the aqueous aldol reaction, between glyoxylic acid, as monohydrate or aqueous solution, and ketones. This reaction led to the formation of chiral α-hydroxy-γ-keto carboxylic acids in

Simple synthesis of ring-fused pyridazin-3-ones

Bicyclic and tricyclic pyridazin-3-ones, 6,7-dihydro-5H-cyclopenta[e]-2H-pyridazin-3-one (5), 5,6,7,8-tetrahydrobenzo[e]-2H-pyridazin-3-one (6), 9,10-dihydronaphtho[1,2-e]-2H-pyridazin-3-one (15) and 9,10-dihydronaphtho[1,2-e]-2-methylpyridazin-3-one (21) were prepared in a one-pot procedure by reacting, hydrazine hydrate with a corresponding ketocarboxylic acid.

Indium trichloride catalysed Mukaiyama aldol reaction in water

In the presence of a catalytic amount of indium(III) chloride (InCl3) (20 mol%), aldehydes react smoothly with ketone trimethylsilyl enol ethers in water to afford the corresponding aldol adducts in good yields.

Polyfunctional (R)-2-Hydroxycarboxylic Acids by Reduction of 2-Oxo Acids with Hydrogen Gas or Formate and Resting Cells of Proteus vulgaris

Various (R)-2-hydroxy acids such as (R)-2-hydroxy-3-enoic-, 3,5-dienoic-, 4-oxo-, (R,S)-3-hydroxy and some others were prepared on a scale up to 0.12 mol by biocatalytic reduction of the corresponding 2-oxo acids with P. vulgaris and hydrogen gas and/or formate as electron donors.With the exception of the 2-hydroxy-4-oxo acids it could be proved that the enantiomeric excess is >97 percent.For the 4-oxo derivatives this enantiomeric excess can be assumed.The yields of isolated products are high because they were isolated from rather small amounts of biocatalyst and low buffer concentrations.Product concentrations in the range of 0.1- 0.24 M were obtained.For 1 mmol of product formation in 15-20 h about 20-40 mg (dry weight) of P. vulgaris cells are necessary.