54682-98-3Relevant academic research and scientific papers
Concise and regioselective synthesis of 5H-imidazo[1,2-e][1,3,5]triazepines
Demydchuk, Bohdan A.,Mykhalchenko, Oleksandr A.,Rusanov, Eduard B.,Moskvina, Viktoriia S.,Brovarets, Volodymyr S.
, (2022/03/27)
In this communication, we report a regioselective synthesis of novel 5H-imidazo[1,2-e][1,3,5]triazepines via the interaction of tetrachloro-2-aza-1,3-butadienes with (1H-imidazol-2-yl)methanamine. The advantages of the presented method are mild reaction conditions, a simple work-up procedure, available reagents, and high yields. A possible mechanism is proposed for the synthesis of key products. The structure of one of the obtained products was proven with asingle crystal X-ray diffraction-based structure.
