54684-07-0Relevant academic research and scientific papers
Synthesis method of m-phenetidine by one-pot reaction
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Paragraph 0033; 0034, (2016/12/07)
The invention discloses a synthesis method of m-phenetidine by a one-pot reaction. The method comprises the following steps: m-aminophenol, alkali and a solvent are thrown into a reaction vessel, and then only an alkylating agent or a catalyst and an alkylating agent are added at the same time, after materials are added, the reaction vessel is enclosed, and stirring is carried out for 0.5-1 hour at room temperature; the temperature is raised to 40-80 DEG C, a reaction is carried out for 1-8 hours, after the reaction, obtained reaction solution is cooled to room temperature and filtered, and filtrate is obtained; reduced pressure distillation for the filtrate is carried out, and m-phenetidine is obtained. The synthesis method of m-phenetidine has the characteristics of low reaction temperature, high safety performance, convenient operation, high purity and high yield of the product, etc.
