5469-10-3Relevant academic research and scientific papers
An improved method for the quaternization of nicotinamide and antifungal activities of its derivatives
Siber, Tamara,Bu?i?, Valentina,Zobund?ija, Dora,Roca, Sun?ica,Viki?-Topi?, Dra?en,Vrande?i?, Karolina,Ga?o-Soka?, Dajana
, (2019/03/26)
The quaternization reactions of nicotinamide, with different electrophiles: methyl iodide and substituted 2-bromoacetophenones (4-Cl, 4-Br, 4-H, 4-CH3, 4-F, 4-OCH3, 4-Ph, 2-OCH3, 4-NO2) are reported. The preparations were carried out by conventional synthesis and under microwave irradiation in absolute ethanol and acetone. The synthesis performed by microwave dielectric heating significantly improved yield, up to 8 times, and shortened down the reaction time from ca. one day in conventional, to 10–20 min. The structures of the synthesized compounds were confirmed by IR, 1H- and 13C-NMR spectroscopy, mass spectrometry and elemental analysis. The compounds have been screened for antifungal activities against Fusarium oxysporum, Fusarium culmorum, Macrophomina phaseolina and Sclerotinia sclerotiorum at concentrations of 10 μg/mL and 100 μg/mL. Six compounds showed the strong inhibition of mycelium growth at a concentration of 10 μg/mL. All tested compounds revealed the great inhibitory activities against S. sclerotiorum at a concentration of 100 μg/mL.
Effect of structure of nucleophile and substrate on the quaternization of heterocyclic amines
Zhuravlev,Verolainen,Voronchikhina
experimental part, p. 1025 - 1028 (2011/01/11)
The influence of the nature of the quaternizing agent and substrate on the quaternization of heterocyclic amines, derivatives of pyridine, ss-picoline, nicotinamide, pyridoxine, was studied. The synthesized compounds were characterized by IR spectroscopy and elemental analysis. The conclusions were made about the effect of the structure of nucleophile and substrate on the process of quaternization reaction. Pleiades Publishing, Ltd., 2010.
