54697-19-7Relevant academic research and scientific papers
A new class of long acting hormonal steroid preparation: synthesis of dimeric ethynodiol and nortestosterone, of dimeric and trimeric androgens and of some dimeric combinations of steroids
Kuhl,Taubert
, p. 613 - 626 (1974)
Dimeric steroid esters containing an estradiol molecule coupled with a molecule of ethynodiol, cortexolone, or ethinylandrostenediol respectively, were synthesized. The same method was also used for dimerization of ethynodiol, nortestosterone, and testosterone, and for the preparation of a trimeric androgen consisting of two molecules testosterone linked by one molecule 5 androsterone 3β,17β diol. The method is based upon the direct esterification of steroid alcohols with steroid hemisuccinates in the presence of N,N' carbonyldiimidazole. The results of preliminary experiments concerning the biological activity of some of these compounds showed a considerable prolongation of hormonal effect as compared to the respective monomer.
EMBODIMENTS OF MONOMER AND OLIGOMER COMPOUNDS AS CONTRACEPTIVES AND THERAPIES AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 97; 100, (2021/12/31)
The invention relates to embodiments of monomer and oligomer compounds intended for use as contraceptive agents. The embodiments of monomer compounds of the present invention comprise substituents that facilitate the ability of the compounds to exhibit pr
