547-44-4

Basic information

• Product Name: SULFANILYLUREA
• Synonyms: SULFANILYLUREA;1-(4-Aminobenzenesulfonyl)urea;1-Amino-4-([(aminocarbonyl)amino]sulfonyl)benzene;1-Sulfanilylurea;4-amino-n-(aminocarbonyl)-benzenesulfonamid;4-Amino-N-(aminocarbonyl)benzenesulfonamide;4-Sulfacarbamide;A 435
• CAS NO: 547-44-4
• Molecular Formula: C₇H₉N₃O₃S
• Molecular Weight: 215.23
• EINECS: 208-922-7
• Product Categories: SULFAUREA
• Mol File: 547-44-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 146-148° (slight dec)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.4565 (rough estimate)
• Refractive Index: 1.6630 (estimate)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: pKa 1.78(H2O t = 25 I = 0.05) (Uncertain);5.42(H2O t = 25 I = 0.05) (Uncertain)
• Water Solubility: 2.333g/L(20 oC)
• CAS DataBase Reference: SULFANILYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: SULFANILYLUREA(547-44-4)
• EPA Substance Registry System: SULFANILYLUREA(547-44-4)

Safety Data

• Hazardous Substances Data: 547-44-4(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

Different sources of media describe the Uses of 547-44-4 differently. You can refer to the following data:
1. antibacterial
2. Sulfacarbamide-d4 is the labeled analogue of Sulfacarbamide (S688945), an antibiotic which is rapidly absorbed in blister fluid.

World Health Organization (WHO)

Sulfacarbamide, a sulfonamide anti-infective agent, was introduced in the 1940's for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. The Sulfacarbamide are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfacarbamide still remains available in at least one country for the treatment of urinary infections.

InChI:InChI=1/C7H9N3O3S/c8-5-1-3-6(4-2-5)14(12,13)10-7(9)11/h1-4H,8H2,(H3,9,10,11)

Upstream product

• 623-11-0 1-methyl-4-nitrosobenzene 
• 57-67-0 1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene 
• 68-35-9 sulfadiazine 
• 127-79-7 sulfamerazina 
• 57-68-1 sulfadimesine 
• 723-46-6 sulfamethoxazole 
• 29177-55-7 N-carbamoyl-4-nitrobenzenesulfonamide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 121-61-9 p-acetylaminobenzenesulfonamide 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 2828-63-9 4-acetylamino-N-carbamoyl-benzenesulfonamide 

Downstream Products

• 73008-53-4 4-(2-benzylidenehydrazino-4-phenyl-thiazol-5-ylazo)-N-carbamoyl-benzenesulfonamide 
• 109054-43-5 C₂₅H₂₃N₇O₅SSe 
• 109054-42-4 C₂₄H₂₁N₇O₄SSe 
• 109054-41-3 C₂₃H₁₉N₇O₄SSe 
• 16589-13-2 C₉H₈Cl₃N₅O₅S₂ 

Relevant articles and documents

-

-

Insight into sulfamethoxazole degradation, mechanism, and pathways by AgBr-BaMoO4 composite photocatalyst

A composite photocatalyst, AgBr-BaMoO4 was fabricated by two step method; microwave hydrothermal and precipitation-deposition. The as prepared photocatalyst samples were characterized by various techniques. The facet coupling was seen between the (204) plane of BaMoO4 and (200)/(222) planes of AgBr on the basis of XRD/HRTEM analysis. The pharmaceutical pollutant, sulfamethoxazole was adopted to investigate the photocatalytic performances of samples under UV–vis irradiation. The AgBr-BaMoO4 composite degraded the aqueous sulfamethoxazole drug in UV–vis light about 64% within 75 min, which was attributed to efficient separation of photogenerated electron–hole pairs across the interface between Ag/AgBr and BaMoO4. The multi-electron induced oxygen reduced reaction (ORR) was observed. The radical trapping experiment indicates that OH? has major role for sulfamethoxazole degradation. The four successive photodegradation of sulfamethoxazole in UV–vis light indicates the stability of composite photocatalyst. Furthermore, the three different degradation pathways were designed on the basis of retention time and molecular masses of 18 degraded organic fragments that was confirmed by high-performance liquid chromatography photodiode array (HPLC-PDA) and high resolution-quadruple time of flight electrospray ionization mass spectroscopy (HR-QTOF ESI/MS) techniques. The total organic carbon (TOC) analysis suggested the mineralization of SMZ by composite photocatalyst. This study not only demonstrates the enhancement of photocatalytic performance of wide band gap semiconductor by making composite with narrow band gap semiconductor but also detail degradation pathways and mechanisms of sulfamethoxazole.