54705-25-8Relevant academic research and scientific papers
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold
Rotondi, Giulia,Guglielmi, Paolo,Carradori, Simone,Secci, Daniela,De Monte, Celeste,De Filippis, Barbara,Maccallini, Cristina,Amoroso, Rosa,Cirilli, Roberto,Akdemir, Atilla,Angeli, Andrea,Supuran, Claudiu T.
, p. 1400 - 1413 (2019/08/26)
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.
Acid-Catalyzed Reactions of Ortho-Substituted Benzohydroxamic Acids in Polyphosphoric Acid (PPA)
Chhaya, P. N.,Nimbalkar, M. M.,Hosangadi, B. D.
, p. 4458 - 4460 (2007/10/02)
Ortho-substituted benzohydroxamic acids undergo a variety of reactions when treated with PPA.The nature of substituents on the ring and on the functional group CONHOH plays a key role in influencing the reaction pathways.The difference in behavior may arise due to change in site of protonation depending upon the substitution.However, no clear-cut relationship could be established as attempts to monitor reactions on NMR proved inconclusive.
