54730-30-2Relevant articles and documents
Flavonoid-triazolyl hybrids as potential anti-hepatitis C virus agents: Synthesis and biological evaluation
Zhang, Han,Zheng, Xin,Li, Jichong,Liu, Qingbo,Huang, Xiao-Xiao,Ding, Huaiwei,Suzuki, Ryosuke,Muramatsu, Masamichi,Song, Shao-Jiang
, (2021)
A series of flavonoid-triazolyl hybrids were synthesized and evaluated as novel inhibitors of hepatitis C virus (HCV). The results of anti-HCV activity assays showed that most of the synthesized derivatives at a concentration of 100 μg/mL inhibited the ge
Furanone compound and preparation method and application thereof
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Paragraph 0044; 0049-0051, (2020/07/13)
The invention discloses a furanone compound and a preparation method and application thereof. P-hydroxybenzaldehyde is used as a raw material, condensed with hydantoin and then subjected to alkaline hydrolysis and esterification to obtain a p-hydroxyphenylpyruvate intermediate; p-hydroxy benzaldehyde and halogenated isopentene are subjected to alkylation, and then benzyl protection is performed toobtain a benzaldehyde derivative intermediate; a benzaldehyde derivative intermediate and a phenylpyruvate intermediate are subjected to aldol condensation and intramolecular esterification under thecatalysis of a condensing agent to synthesize novel furanone compounds BL5 and BL10. The furanone derivative has H1N1 virus inhibition activity, and can be used for preparing medicines for treating H1N1 virus infection.
Concise, stereocontrolled and modular syntheses of the anti-influenza rubrolides R and S
Moreira, Thaís A.,Lafleur-Lambert, Rapha?l,Barbosa, Luiz C.A.,Boukouvalas, John
supporting information, (2019/11/13)
The fungal metabolites rubrolide R and S were synthesized in concise, entirely stereoselective fashion through the combined use of bromine-stereodirected vinylogous aldol condensation (SVAC) and Suzuki cross-coupling. A bioinspired, high-yield conversion