1608121-24-9

Upstream product

• 71597-85-8 (p-hydroxyphenyl)boronic acid 
• 61370-75-0 3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-6-carboxaldehyde 
• 78-79-5 isoprene 
• 123-08-0 4-hydroxy-benzaldehyde 
• 7706-90-3 4-(4-hydroxyphenyl)furan-2(5H)-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 54730-30-2 4-hydroxy-3-C-prenylbenzaldehyde 
• 3516-65-2 4-(4-methoxyphenyl)furan-2(5H)-one 
• 99142-77-5 methyl (E)-3-(3-methoxyphenyl)-3-methylacrylate 

Downstream Products

• 1608121-21-6 (Z)-5-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzylidene)-4-(4-hydroxyphenyl)furan-2(5H)-one 

Relevant academic research and scientific papers

Protecting-Group-Free Total Syntheses of Rubrolide R and S

The two marine natural products rubrolide R (1) and S (2) were synthesised in only three linear steps starting from commercially available tetronic acid without using protecting-group chemistry. Key steps in the syntheses were the Pd-catalysed Suzuki–Miya

Concise, stereocontrolled and modular syntheses of the anti-influenza rubrolides R and S

The fungal metabolites rubrolide R and S were synthesized in concise, entirely stereoselective fashion through the combined use of bromine-stereodirected vinylogous aldol condensation (SVAC) and Suzuki cross-coupling. A bioinspired, high-yield conversion

Efficient, collective synthesis and nitric oxide inhibitory activity of rubrolides E, F, R, S and their derivatives

An efficient first synthesis of biologically significant natural butenolides, rubrolides F (1f), R (1r), S (1s) & its 7″,8″-didehydro derivative (1sa), and 3″-bromo rubrolide (1fa) along with the synthesis of rubrolide E (1e) and its di-O-methyl derivative (1ea) is accomplished in a collective fashion from commercially available and inexpensive precursors in overall yields of 14–48.5%. Key features are Wittig-Horner reaction, SeO2-induced tandem allylic hydroxylation/intramolecular cyclization and Knoevenagel condensation. Next, in their inhibitory activity towards nitric oxide (NO) production in lipopolysaccharide-induced RAW 264.7 macrophages as an indicator of anti-inflammatory activity, all compounds displayed good inhibitory activity in a concentration-dependent manner. None of the compound exhibited notable cytotoxicity at the highest concentration (10?μM) and IC50values are found in the range from 8.53 to 17.85?μM.