54742-79-9Relevant academic research and scientific papers
Discovery of diaryl imidazolidin-2-one derivatives, a novel class of muscarinic M3 selective antagonists (Part 2)
Peretto, Ilaria,Fossati, Claudia,Giardina, Giuseppe A. M.,Giardini, Alessandra,Guala, Matilde,La Porta, Elena,Petrillo, Paola,Radaelli, Stefano,Radice, Luigi,Raveglia, Luca F.,Santoro, Enza,Scudellaro, Roberta,Scarpitta, Francesca,Cerri, Alberto,Menegon, Sergio,Dondio, Giulio M.,Rizzi, Andrea,Armani, Elisabetta,Amari, Gabriele,Civelli, Maurizio,Villetti, Gino,Patacchini, Riccardo,Bergamaschi, Marco,Bassani, Franco,Delcanale, Maurizio,Imbimbo, Bruno P.
, p. 1693 - 1697 (2008/02/11)
Synthesis and biological activity of a novel class of quaternary ammonium salt muscarinic M3 receptor antagonists, showing high selectivity versus the M2 receptor, are described. Selected compounds exhibited potent anticholinergic properties, in isolated guinea-pig trachea, and good functional selectivity for trachea over atria. In vivo, the same compounds potently inhibited acetylcholine-induced bronchoconstriction after intratracheal administration in the guinea pig.
3-alkyl-(5,5'-diphenyl)imidazolidinediones as new cannabinoid receptor ligands
Kanyonyo, Martial,Govaerts, Sophie J.,Hermans, Emmanuel,Poupaert, Jacques H.,Lambert, Didier M.
, p. 2233 - 2236 (2007/10/03)
Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.
