54765-14-9

Basic information

• Product Name: 2-oxyethyl pyridine
• Synonyms: 2-oxyethyl pyridine;2-(pyridin-2-yl)acetaldehyde
• CAS NO: 54765-14-9
• Molecular Formula: C₇H₇NO
• Molecular Weight: 121
• Mol File: 54765-14-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 211.6±15.0 °C(Predicted)
• Appearance: /
• Density: 1.074±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 4.62±0.12(Predicted)
• CAS DataBase Reference: 2-oxyethyl pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-oxyethyl pyridine(54765-14-9)
• EPA Substance Registry System: 2-oxyethyl pyridine(54765-14-9)

Safety Data

• Hazardous Substances Data: 54765-14-9(Hazardous Substances Data)

Usage

General Description

2-oxyethyl pyridine is a chemical compound that belongs to the group of alkyl pyridines. It is a colorless to yellow liquid with a pungent odor and is commonly used as a solvent in various industrial processes, such as in the manufacturing of pharmaceuticals, agrochemicals, and dyes. It is also used as an intermediate in the production of other chemicals. 2-oxyethyl pyridine is considered to be a hazardous chemical and should be handled with caution due to its potential health effects, including skin and eye irritation, and respiratory issues. It is important to use proper safety measures and personal protective equipment when working with this chemical.

Upstream product

• 6304-27-4 2-<-(dimethylamino)ethyl>pyridine 

Downstream Products

• 56759-30-9 (E)-4-methylphenyl 2-(2-pyridinyl)ethenyl sulfone 
• 2739-97-1 pyridine-2-acetonitrile 
• 26414-86-8 2-(pyridin-2-yl)-thioacetamide 
• 352298-75-0 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[2-(2-pyridin-2-yl-ethylamino)-propyl]-1H-pyrimidine-2,4-dione 
• 352298-76-1 1-(2,6-difluoro-benzyl)-5-(3-methoxy-phenyl)-6-methyl-3-[2-(2-pyridin-2-yl-ethylamino)-propyl]-1H-pyrimidine-2,4-dione 
• 667911-32-2 tert-butyl 5-(pyridin-2-ylmethylamino)pentylcarbamate 

Relevant articles and documents

Kinetics and mechanism of aliphatic amine oxidation by aqueous (batho)2CuII

The kinetics of oxidation of a large series of aliphatic amines by the "high-potential" oxidant (batho)2CuII (batho = 2,9-dimethyl-4,7-diphenyl-1,10-phenanthrolinedisulfonate) was studied under pseudo-first-order conditions (excess amine) in water or in 30% aqueous methanol (v/v) at 25 °C over the pH range 7-11. The oxidations follow bell-shaped pH-rate profiles, with the low-pH leg reflecting the fact that only the free amine base is subject to oxidation and the high-pH leg representing conversion of (batho)2CuII to an ineffective oxidant at high pH. The latter is thought to be (batho)CuII(OH2)OH on the basis of the observed effect of [batho] on rate at high pH, and curve fitting of the rate data yielded estimates of the unitless Keq values governing this conversion. The variation in rate with degree of N-substitution and other structure-reactivity trends (such as the effect of ring size and the non-rate-retarding effect of 2,4,6-trimethyl substitution on PhCH2NR2) support a mechanism involving initial outer-sphere one-electron transfer, followed by proton transfer to the solvent, and then a rapid second one-electron oxidation to give imine/iminium product. Inner-sphere coordination of chelating amines shuts down the redox reaction, presumably as a consequence of displacement of the batho ligand(s) needed for high oxidant strength. Deuterium kinetic isotope effect (DKIE) measurements (i) comparing PhCD2N(CD3)2 vs PhCH2N(CH3)2 (intermolecular DKIE) and (ii) determining N-dealkylation preference in the case of PhCH2N(CH3)CD2Ph (intramolecular DKIE) suggest that the initial electron transfer is mainly rate-limiting. A rate comparison between erythro and threo diastereomers of 1,2-diphenyl-2-piperidinoethanol indicates a stereoelectronic preference for one-electron oxidation at nitrogen when held antiperiplanar to a β-hydroxyl. Stoichiometry studies using an excess of the Cu(II) oxidant reveal regioselective and chemoselective factors governing the overall amine-to-iminium oxidations.