547739-66-2

Upstream product

• 118-91-2 ortho-chlorobenzoic acid 
• 137-64-4 2-chloro-5-(chlorosulfonyl)benzoic acid 

Downstream Products

• 866763-13-5 4-chloro-3-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-ylcarbamoyl)-benzenesulfonyl chloride 
• 330209-89-7 2-chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-5-diethylsulfamoyl-benzamide 
• 782471-01-6 (2,4-dichloro-5-(piperidine-1-sulfonyl)phenyl)methanol 
• 1235560-43-6 4-chloro-3-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]-N-[4-(trifluoromethyl)phenyl]benzenesulfonamide 

Relevant academic research and scientific papers

Synthesis of new sulfonamide derivatives of thiazolo[3,2-a]quinazolin-5-one

A general procedure has been proposed for the synthesis of thiazolo[3,2-a]quinazolin-5-one derivatives containing a sulfonamide group on C7via intramolecular nucleophilic substitution of halogen in 2-halo-5-sulfamoyl-N-(1,3-thiazol-2-yl)benzami

NOVEL BENZENESULFONAMIDES AS CALCIUM CHANNEL BLOCKERS

The present application relates to calcium channel inhibitors comprising compounds of formula (I), formula (II), formula (III), or formula (IV), wherein L1, R1, R2, R3, R4, R5, R6, R7 and Rc are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions.

THERAPEUTIC COMPOUNDS

The present invention provides novel compounds that function as potentiators of glutamate receptors, methods for their preparation, pharmaceutical compositions containing them, and methods of their use in therapy.

Structure-activity relationships of novel potent MurF inhibitors

A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC 50=22～70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.