330209-89-7Relevant academic research and scientific papers
Structure-activity relationships of novel potent MurF inhibitors
Gu, Yu Gui,Florjancic, Alan S.,Clark, Richard F.,Zhang, Tianyuan,Cooper, Curt S.,Anderson, David D.,Lerner, Claude G.,McCall, J. Owen,Cai, Yingna,Black-Schaefer, Candace L.,Stamper, Geoffrey F.,Hajduk, Philip J.,Beutel, Bruce A.
, p. 267 - 270 (2007/10/03)
A novel class of MurF inhibitors was discovered and structure-activity relationship studies have led to several potent compounds with IC 50=22～70 nM. Unfortunately, none of these potent MurF inhibitors exhibited significant antibacterial activity even in the presence of bacterial cell permeabilizers.
