547740-66-9Relevant academic research and scientific papers
New results on the reactivity of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine
Cosimelli, Barbara,Iadanza, Manuela,Spisani, Raffaella,Novellino, Ettore
, p. 883 - 886 (2004)
The reaction of 5,6-diamino-4-hydroxy-2-mercaptopyrimidine with mono- and α,ω-dihalocompounds has been reinvestigated. Alkyl derivatives of 5-amino group, not previously described, have been obtained as reaction products. A comparison with the reactivity of 6-amino-4-hydroxy-2- mercaptopyrimidine has been also performed.
Pteridine-based fluorescent pH sensors designed for physiological applications
Saleh, Na'Il,Graham, John,Afaneh, Akef,Schreckenbach, Georg,Al-Soud, Yaseen A.,Esmadi, Fatima T.
, p. 63 - 73,11 (2020/08/20)
New derivatives of pteridine, namely 6,7-diphenyl-2-morpholinylpterin (DMPT) and 6-thienyllumazine (TLM) were designed and easily synthesized in a rational way for pH-fluorescence sensing near physiological pH. The dual-excitation ratiometric sensing was
Preliminary finding on a new calcium channel entry blocker chemotype: 5,6-diamino-4-hydroxy-2-mercaptopyrimidine derivatives
Cosimelli, Barbara,Severi, Elda,Novellino, Ettore,Cavaccini, Anna,Cataldi, Mauro,Budriesi, Roberta,Micucci, Matteo,Chiarini, Alberto,Ioan, Pierfranco
scheme or table, p. 5597 - 5601 (2011/10/02)
We report the preliminary in vitro characterization of a series of pyrimidines as a new chemotype that modulates cardiovascular parameters and relaxes ileum smooth muscle according to classical calcium entry blockers. Tested compounds showed an interestin
A prototype solid phase synthesis of pteridines and related heterocyclic compounds
Gibson, Colin L.,La Rosa, Salvatore,Suckling, Colin J.
, p. 1909 - 1918 (2007/10/03)
The development of a versatile solid phase synthesis of bicyclic polyaza heterocycles including pteridines, purines, and deazapurines is described. The strategy comprises the linking of a pre-formed pyrimidine through a thioether at the 2 or 4 position to a polystyrene resin, the cyclisation of the second ring, and the direct or oxidative cleavage of the product from the resin by nucleophilic substitution. This provides not only for substituent variation in the second ring, but also for variation at the site of cleavage. Limitations in the scope of the methodology are set by the intrinsic reactivity of pyrimidinyl 2- or 4-thioethers which, whilst undergoing ready nitration at C5, are surprisingly difficult to alkylate and acylate.
Syntheses of highly functionalised 6-substituted pteridines.
Guiney, Donie,Gibson, Colin L,Suckling, Colin J
, p. 664 - 675 (2007/10/03)
Methods for the synthesis of polyfunctional 6-substituted pteridines from the corresponding 6-aldehydes are described. Alkene, ester, ketone, amide, cyano, oxime, bromo, methoxy and dihydroxy functional groups have all been introduced principally through
