54777-54-7

Basic information

• Product Name: 2-(2-Chloroethyl)-1-methylpyrrolidine
• Synonyms: 2-(2-Chloroethyl)-1-methylpyrrolidine;1-Methyl-2-(2-chloroethyl)pyrrolidine;Pyrrolidine,2-(2-chloroethyl)-1-methyl-
• CAS NO: 54777-54-7
• Molecular Formula: C₇H₁₄ClN
• Molecular Weight: 147.64576
• Mol File: 54777-54-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 120-122 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 181.5 °C at 760 mmHg
• Flash Point: 63.6 °C
• Appearance: /
• Density: 0.992 g/cm³
• Vapor Pressure: 0.849mmHg at 25°C
• Refractive Index: 1.462
• PKA: 10.13±0.40(Predicted)
• CAS DataBase Reference: 2-(2-Chloroethyl)-1-methylpyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Chloroethyl)-1-methylpyrrolidine(54777-54-7)
• EPA Substance Registry System: 2-(2-Chloroethyl)-1-methylpyrrolidine(54777-54-7)

Safety Data

• Hazardous Substances Data: 54777-54-7(Hazardous Substances Data)

Usage

Uses

2-(2-Chloroethyl)-1-methylpyrrolidine is an intermediate used in synthesis of SIB 1553A Hyrdrochloride (S411000).

InChI:InChI=1/C7H14ClN/c1-9-6-2-3-7(9)4-5-8/h7H,2-6H2,1H3

Upstream product

• 67004-64-2 2-(1-methyl-2-pyrrolidine)ethanol 
• 56824-22-7 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride 
• 67-66-3 chloroform 

Downstream Products

• 79893-35-9 1-allyl-2-[2-methoxy 3,5-dichlorophenoxyethyl]pyrrolidine fumarate 
• 1215098-55-7 2-(4-bromo-phenyl)-4-(1-methyl-pyrrolidin-2-yl)-butyronitrile 

Relevant articles and documents

Preparation method of clemastine fumarate

The invention relates to a preparation method of clemastine fumarate, which comprises the following steps of: step 1: performing chlorination substitution on hydroxyl by taking N-methyl-2-(2-ethoxyl) pyrrolidine as a starting material to prepare N-methyl-(2-chloroethyl) pyrrolidine, step 2: allowing N-methyl-(2-chloroethyl) pyrrolidine and 1-(4-chlorphenyl)-1-phenyl alcohol to react as raw materials by the action of sodamide to form racemic clemastine and then adding succinic acid to prepare racemic clemastine succinate, step 3: performing splitting by using L-(+)-tartaric acid in acetone and water by taking racemic clemastine succinate as a raw material, adding fumaric acid for salification to form a crude product of clemastine fumarate, and step 4: performing recrystallization on the crude product of clemastine fumarate by using an acetone aqueous solution to form a pure product of clemastine fumarate.