54778-22-2

Upstream product

• 38367-40-7 2-chloro-1-phenyl-1H-indole-3-carbaldehyde 

Downstream Products

• 63793-62-4 2-chloro-1-phenyl-indole-3-carbonyl chloride 
• 1174929-06-6 4-(2-chloro-1-phenyl-1H-indole-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 120110-19-2 1-(4-Chloro-phenyl)-3-(2-chloro-1-phenyl-1H-indole-3-carbonyl)-urea 
• 120110-13-6 2-chloro-1-phenyl-1H-indole-3-carboxylic acid amide 

Relevant academic research and scientific papers

Substituted indoles as inhibitors of poly (ADP-ribose) polymerase (PARP)

The present invention relates to a series of substituted indole derivatives of the formula I: wherein R, R1, R2, R3, R4, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are inhibitors of poly(adenosine 5′-diphosphate ribose) polymerase (PARP) and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases, including diseases associated with the central nervous system and cardiovascular disorders.